Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2937179 | 1.00 | SLC6A2 (0.53) | SLC6A2SLC6A3SLC6A4DRD4DRD2 | |
| SCHEMBL2933070 | 0.86 | ABCB1 (0.47) | SLC6A2SLC6A3DRD4DRD2KDM4E | |
| SCHEMBL3017719 | 0.83 | SIGMAR1 (0.51) | SLC6A2SLC6A3DRD4TSHRSIGMAR1 | |
| SCHEMBL3356592 | 0.79 | DRD4 (0.55) | DRD4DRD2CHRNA7KDM4ETSHR | |
| SCHEMBL9015945 | 0.77 | LMNA (0.50) | DRD4DRD2CHRNA7KDM4ETSHR | |
| SCHEMBL10510000 | 0.77 | HTR1D (0.40) | SLC6A2SLC6A3SLC6A4HTR1AADRB2 | |
| SCHEMBL28212829 | 0.76 | HTR7 (0.45) | SLC6A2SLC6A3SLC6A4DRD4DRD2 | |
| Fluoride SCHEMBL28212837 | 0.76 | HTR7 (0.45) | SLC6A2SLC6A3SLC6A4DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL10511305 | 0.76 | HTR1D (0.40) | SLC6A2SLC6A3SLC6A4KDM4EHTR1A | |
| SCHEMBL1183937 | 0.75 | AKR1C3 (0.47) | SLC6A2SLC6A3SLC6A4KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229362-A1 | PIPERAZINES AS ANTI-OBESITY AGENTS | AstraZeneca AB (SE) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009071658-A1 | PIPERAZINES AS ANTI-OBESITY AGENTS | BIOVITRUM AB (PUBL) (SE) | 2009-06-11 | — | — | WO | disclosed |