Streptonigrin

Streptonigrin

SCHEMBL29371276

COC1=C(N)C(=O)c2nc(-c3nc(C(=O)O)c(C)c(-c4ccc(OC)c(OC)c4O)c3N)ccc2C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 1.00
▸ LMNA P02545 3/20 1.00
▸ SMN1; SMN2 Q16637 3/20 1.00
▸ NPC1 O15118 3/20 1.00
▸ RAB9A P51151 3/20 1.00
▸ POLB P06746 2/20 1.00
▸ MAPK1 P28482 2/20 1.00
▸ MEN1 O00255 2/20 1.00
▸ KMT2A Q03164 2/20 1.00
▸ PDE4A P27815 2/20 1.00
▸ PDE4B Q07343 2/20 1.00
▸ PDE4C Q08493 2/20 1.00
▸ PDE4D Q08499 2/20 1.00
▸ PADI1 Q9ULC6 2/20 1.00
▸ PADI3 Q9ULW8 2/20 1.00
▸ PADI4 Q9UM07 2/20 1.00
▸ PADI2 Q9Y2J8 2/20 1.00
▸ KDM4E B2RXH2 1/20 1.00
▸ TGM2 P21980 1/20 1.00
▸ GALK1 P51570 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Streptonigrin SCHEMBL29821157 1.00 MAPT (1.00) MAPTLMNASMN1; SMN2NPC1RAB9A
Streptonigrin SCHEMBL3940 1.00 MAPT (1.00) MAPTLMNASMN1; SMN2NPC1RAB9A
Streptonigrin SCHEMBL29374011 1.00 MAPT (1.00) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL25015126 0.93 MAPT (0.87) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL30260509 0.93 MAPT (0.87) MAPTLMNASMN1; SMN2NPC1RAB9A
Streptonigrin SCHEMBL23421492 0.92 LMNA (0.85) MAPTLMNASMN1; SMN2NPC1RAB9A
Streptonigrin SCHEMBL6299739 0.91 LMNA (0.84) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL23484220 0.89 FNTA (0.82) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL20257205 0.85 SMN1; SMN2 (0.75) MAPTLMNASMN1; SMN2NPC1RAB9A
SCHEMBL29885591 0.82 LMNA (0.70) MAPTLMNASMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 360 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4743490-A1 HUMANIZED ANTI-CD7 ANTIBODY Christian-Albrechts-Universität zu Kiel (DE) 2026-05-20 — — EP claimed
WO-2026099502-A1 NOVEL DRUG CONJUGATES FOR TESTING CELLULAR DRUG UPTAKE Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2026-05-15 — — WO claimed
EP-4676544-A1 ANTIBODY-DRUG CONJUGATE COMPRISING ANTIBODIES AGAINST HUMAN L1CAM AND USES THEREOF LigaChem Biosciences Inc. (KR) 2026-01-14 — — EP claimed
EP-3277381-B1 NITROBENZYL DERIVATIVES OF ANTI-CANCER AGENTS OBI PHARMA INC (TW) 2026-01-07 — — EP claimed
EP-4642492-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE FUNCTIONAL SMALL MOLECULE COMPOUNDS FOR ENHANCED TREATMENT OF REFRACTORY DISEASES Hangzhou Seehe Biotechnology Co., Ltd (CN) 2025-11-05 — — EP claimed
US-20250242043-A1 ANTIBODY-DRUG CONJUGATE COMPRISING ANTIBODY AGAINST HUMAN TROP2 AND USE THEREOF LIGACHEM BIOSCIENCES, INC. (KR) 2025-07-31 — — US claimed
EP-4504272-A1 ANTIBODY-DRUG CONJUGATE COMPRISING ANTIBODY AGAINST HUMAN TROP2 AND USE THEREOF LigaChem Biosciences Inc. (KR) 2025-02-12 — — EP claimed
WO-2025012080-A1 HUMANIZED ANTI-CD7 ANTIBODY CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL (DE) 2025-01-16 — — WO claimed
US-12168060-B2 Antibody-drug conjugates comprising anti-B7-H3 antibodies INTOCELL, INC. (KR) 2024-12-17 — — US claimed
WO-2024240173-A1 AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE FUNCTIONAL SMALL MOLECULE COMPOUNDS FOR ENHANCED TREATMENT OF REFRACTORY DISEASES HANGZHOU SEEHE BIOTECHNOLOGY CO., LTD (CN) 2024-11-28 — — WO claimed
US-11413353-B2 Conjugates comprising self-immolative groups and methods related thereto LEGOCHEM BIOSCIENCES, INC. (KR) 2022-08-16 — — US claimed
US-20220226496-A1 LIGAND-DRUG CONJUGATE INCLUDING LINKER HAVING TRIS STRUCTURE LEGOCHEM BIOSCIENCES, INC. (KR) 2022-07-21 — — US claimed
US-20220218840-A1 ANTIBODY-DRUG CONJUGATES COMPRISING BRANCHED LINKERS AND METHODS RELATED THERETO LIGACHEM BIOSCIENCES INC. (KR) 2022-07-14 — — US claimed
EP-4025257-A1 ANTIBODY-DRUG CONJUGATE COMPRISING ANTIBODY AGAINST HUMAN ROR1, AND USE FOR THE SAME LegoChem Biosciences, Inc. (KR) 2022-07-13 — — EP claimed
US-20220202950-A1 COMPOSITIONS COMPRISING BACTERIALLY DERIVED INTACT MINICELLS FOR THERANOSTIC APPLICATIONS ENGENEIC MOLECULAR DELIVERY PTY LTD (AU) 2022-06-30 — — US claimed
WO-2022078524-A2 SPECIFIC CONJUGATION OF AN ANTIBODY HANGZHOU DAC BIOTECH CO., LTD. (CN) 2022-04-21 — — WO claimed
EP-3218007-B1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCER INST NAT SANTE RECH MED (FR) 2022-04-06 — — EP claimed
EP-3964236-A1 LIGAND-DRUG CONJUGATE INCLUDING LINKER HAVING TRIS STRUCTURE LegoChem Biosciences, Inc. (KR) 2022-03-09 — — EP claimed
US-20220047717-A1 ANTIBODY-DRUG CONJUGATES COMPRISING ANTI-B7-H3 ANTIBODIES Y-Biologics Inc. (KR) 2022-02-17 — — US claimed
EP-3316878-B1 METHODS AND COMPOUNDS FOR THE ALLEVIATION OF PAIN CATRINA ANCA (SE) 2022-02-09 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220047717-A1 ANTIBODY-DRUG CONJUGATES COMPRISING ANTI-B7-H3 ANTIBODIES CD274, CD44, H1-3 MAPT 1100/4885LMNA 3972/4885SMN1; SMN2 3166/4885
US-20220226496-A1 LIGAND-DRUG CONJUGATE INCLUDING LINKER HAVING TRIS STRUCTURE TNFSF10, TNFRSF9, ANTXR2 MAPT 412/4885LMNA 1824/4885SMN1; SMN2 2841/4885
US-20250242043-A1 ANTIBODY-DRUG CONJUGATE COMPRISING ANTIBODY AGAINST HUMAN TROP2 AND USE THEREOF CAMK2D, CD2BP2, CD22 MAPT 892/4885LMNA 4694/4885SMN1; SMN2 2218/4885
US-12168060-B2 Antibody-drug conjugates comprising anti-B7-H3 antibodies CD274, CD44, H1-3 MAPT 1100/4885LMNA 3972/4885SMN1; SMN2 3166/4885
US-20220218840-A1 ANTIBODY-DRUG CONJUGATES COMPRISING BRANCHED LINKERS AND METHODS RELATED THERETO PA2G4, FCGRT, CLTB MAPT 870/4885LMNA 4443/4885SMN1; SMN2 4519/4885
US-11413353-B2 Conjugates comprising self-immolative groups and methods related thereto LPO, NOXO1, DAO MAPT 933/4885LMNA 4316/4885SMN1; SMN2 3541/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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