Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | MAPT | P10636 | 2/20 | 0.75 |
| ▸ | NPC1 | O15118 | 2/20 | 0.75 |
| ▸ | RAB9A | P51151 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | TGM2 | P21980 | 1/20 | 0.75 |
| ▸ | PDE4A | P27815 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | GALK1 | P51570 | 1/20 | 0.75 |
| ▸ | BLM | P54132 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.75 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.75 |
| ▸ | EP300 | Q09472 | 1/20 | 0.75 |
| ▸ | ATM | Q13315 | 1/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30260509 | 0.93 | MAPT (0.87) | SMN1; SMN2KDM4EMAPTNPC1RAB9A | |
| SCHEMBL25015126 | 0.93 | MAPT (0.87) | SMN1; SMN2KDM4EMAPTNPC1RAB9A | |
| SCHEMBL20250622 | 0.89 | FNTA (0.65) | SMN1; SMN2KDM4EMAPTNPC1RAB9A | |
| Streptonigrin SCHEMBL29371276 | 0.85 | MAPT (1.00) | SMN1; SMN2KDM4EMAPTNPC1RAB9A | |
| Streptonigrin SCHEMBL29374011 | 0.85 | MAPT (1.00) | SMN1; SMN2KDM4EMAPTNPC1RAB9A | |
| Streptonigrin SCHEMBL29821157 | 0.85 | MAPT (1.00) | SMN1; SMN2KDM4EMAPTNPC1RAB9A | |
| SCHEMBL23484180 | 0.85 | FNTA (0.70) | SMN1; SMN2KDM4EMAPTNPC1RAB9A | |
| Streptonigrin SCHEMBL23421492 | 0.79 | LMNA (0.85) | SMN1; SMN2KDM4EMAPTNPC1RAB9A | |
| Streptonigrin SCHEMBL6299739 | 0.78 | LMNA (0.84) | SMN1; SMN2KDM4EMAPTNPC1RAB9A | |
| SCHEMBL23484220 | 0.78 | FNTA (0.82) | SMN1; SMN2KDM4EMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11052154-B2 | Ras protein degradation inducing molecule and pharmaceutical composition | TOKYO UNIVERSITY OF SCIENCE FOUNDATION (JP) | 2021-07-06 | — | — | US | disclosed |
| US-11007269-B2 | P53 degradation inducing molecule and pharmaceutical composition | TOKYO UNIVERSITY OF SCIENCE FOUNDATION (JP) | 2021-05-18 | — | — | US | disclosed |
| US-10976306-B2 | Protein degradation inducing tag and usage thereof | TOKYO UNIVERSITY OF SCIENCE FOUNDATION (JP) | 2021-04-13 | — | — | US | disclosed |
| US-20210088504-A1 | PROTEIN DEGRADATION INDUCING TAG AND USAGE THEREOF | TOKYO UNIVERSITY OF SCIENCE FOUNDATION (JP) | 2021-03-25 | — | — | US | disclosed |
| US-20190314508-A1 | P53 DEGRADATION INDUCING MOLECULE AND PHARMACEUTICAL COMPOSITION | TOKYO UNIVERSITY OF SCIENCE FOUNDATION (JP) | 2019-10-17 | — | — | US | disclosed |
| US-20180164289-A1 | PROTEIN DEGRADATION INDUCING TAG AND USAGE THEREOF | TOKYO UNIVERSITY OF SCIENCE FOUNDATION (JP) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10976306-B2 | Protein degradation inducing tag and usage thereof | SENP8, SENP6, SENP7 | SMN1; SMN2 4697/4885KDM4E 2997/4885MAPT 1694/4885 |
| US-20190314508-A1 | P53 DEGRADATION INDUCING MOLECULE AND PHARMACEUTICAL COMPOSITION | TP53, TP53BP1, MDM2 | SMN1; SMN2 4754/4885KDM4E 4133/4885MAPT 336/4885 |
| US-11052154-B2 | Ras protein degradation inducing molecule and pharmaceutical composition | KRAS, G3BP1, NRAS | SMN1; SMN2 4496/4885KDM4E 4086/4885MAPT 1805/4885 |
| US-20180164289-A1 | PROTEIN DEGRADATION INDUCING TAG AND USAGE THEREOF | SENP8, SENP6, SENP7 | SMN1; SMN2 4697/4885KDM4E 2997/4885MAPT 1694/4885 |
| US-20210088504-A1 | PROTEIN DEGRADATION INDUCING TAG AND USAGE THEREOF | SENP8, SENP6, SENP7 | SMN1; SMN2 4697/4885KDM4E 2997/4885MAPT 1694/4885 |
| US-11007269-B2 | P53 degradation inducing molecule and pharmaceutical composition | TP53, TP53BP1, MDM2 | SMN1; SMN2 4754/4885KDM4E 4133/4885MAPT 336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.