SCHEMBL29374335

SCHEMBL29374335

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nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ACE P12821 3/20 0.36
MME P08473 1/20 0.35
CPA1 P15085 1/20 0.35
ACE2 Q9BYF1 1/20 0.35
CTSC P53634 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21828612 1.00 ACE (0.36) ACEMMECPA1ACE2CTSC
SCHEMBL31064827 0.95 BACE1 (0.35) ACE
SCHEMBL29384990 0.93 ACE (0.38) ACEMME
SCHEMBL79320 0.92 ACE (0.36) ACEMMECPA1ACE2CTSC
SCHEMBL78173 0.92 ACE (0.36) ACEMMECPA1ACE2CTSC
SCHEMBL78174 0.92 ACE (0.36) ACEMMECPA1ACE2CTSC
SCHEMBL29532207 0.91 MME (0.41) MME
SCHEMBL29849128 0.90 MME (0.36) ACEMME
SCHEMBL29961809 0.90 MME (0.45) ACEMMECPA1ACE2
SCHEMBL29517172 0.90 ERAP2 (0.35) ACE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4737477-A2 HEPCIDIN MIMETICS FOR TREATMENT OF HEREDITARY HEMOCHROMATOSIS Protagonist Therapeutics, Inc. (US) 2026-05-06 EP claimed
EP-4706671-A2 CONJUGATED HEPCIDIN MIMETICS Protagonist Therapeutics, Inc. (US) 2026-03-11 EP claimed
US-20250340608-A1 HEPCIDIN ANALOGUES AND USES THEREOF PROTAGONIST THERAPEUTICS, INC. (US) 2025-11-06 US claimed
EP-4536683-A1 HEPCIDIN MIMETICS FOR TREATMENT OF SICKLE CELL DISEASE Protagonist Therapeutics, Inc. (US) 2025-04-16 EP claimed
US-20240293511-A1 HEPCIDIN MIMETICS FOR TREATMENT OF HEREDITARY HEMOCHROMATOSIS PROTAGONIST THERAPEUTICS, INC. 2024-09-05 US claimed
US-20240226225-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2024-07-11 US claimed
EP-4355763-A1 HEPCIDIN MIMETICS FOR TREATMENT OF HEREDITARY HEMOCHROMATOSIS Protagonist Therapeutics, Inc. (US) 2024-04-24 EP claimed
EP-4314014-A2 CONJUGATED HEPCIDIN MIMETICS Protagonist Therapeutics, Inc. (US) 2024-02-07 EP claimed
CN-117480176-A Hepcidin mimetics for the treatment of hereditary hemochromatosis 领导医疗有限公司 2024-01-30 CN claimed
US-20240018189-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2024-01-18 US claimed
US-20230295259-A1 Conjugated Hepcidin Mimetics PROTAGONIST THERAPEUTICS, INC. 2023-09-21 US claimed
CN-116457000-A Conjugated hepcidin mimetics 普罗塔格尼斯特治疗股份有限公司 2023-07-18 CN claimed
EP-4188412-A1 CONJUGATED HEPCIDIN MIMETICS Protagonist Therapeutics, Inc. (US) 2023-06-07 EP claimed
WO-2022266060-A1 HEPCIDIN MIMETICS FOR TREATMENT OF HEREDITARY HEMOCHROMATOSIS PROTAGONIST THERAPEUTICS, INC. (US) 2022-12-22 WO claimed
US-20220372099-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. 2022-11-24 US claimed
WO-2022212698-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2022-10-06 WO claimed
WO-2022212700-A2 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2022-10-06 WO claimed
EP-4025592-A1 CONJUGATED HEPCIDIN MIMETICS Protagonist Therapeutics, Inc. (US) 2022-07-13 EP claimed
CN-114729022-A Conjugated hepcidin mimetics 领导医疗有限公司 2022-07-08 CN claimed
WO-2022026631-A1 CONJUGATED HEPCIDIN MIMETICS PROTAGONIST THERAPEUTICS, INC. (US) 2022-02-03 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240018189-A1 CONJUGATED HEPCIDIN MIMETICS HAMP, VIP, HDGF ACE 3636/4885MME 612/4885CPA1 348/4885
US-20230295259-A1 Conjugated Hepcidin Mimetics HAMP, VIP, HDGF ACE 3636/4885MME 612/4885CPA1 348/4885
US-20240293511-A1 HEPCIDIN MIMETICS FOR TREATMENT OF HEREDITARY HEMOCHROMATOSIS HAMP, SLC40A1, FTH1 ACE 3776/4885MME 496/4885CPA1 959/4885
US-20250340608-A1 HEPCIDIN ANALOGUES AND USES THEREOF HAMP, SLC40A1, FTH1 ACE 2978/4885MME 345/4885CPA1 584/4885
US-20220372099-A1 CONJUGATED HEPCIDIN MIMETICS HAMP, HDGF, FTH1 ACE 4511/4885MME 2195/4885CPA1 874/4885
US-20240226225-A1 CONJUGATED HEPCIDIN MIMETICS HAMP, SLC40A1, FTH1 ACE 4405/4885MME 809/4885CPA1 933/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.