Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | BCL9 | O00512 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27872409 | 0.84 | MAPT (0.44) | ATMTDP1RAPGEF3MAPTKDM4E | |
| SCHEMBL3183674 | 0.83 | TSHR (0.51) | MAPTKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL3964966 | 0.82 | AR (0.47) | SMN1; SMN2MEN1KMT2ALMNAHTT | |
| SCHEMBL27578594 | 0.82 | BCL9 (0.61) | ATMTDP1RAPGEF3MAPTKDM4E | |
| SCHEMBL4612031 | 0.81 | BCL9 (0.35) | MAPTKDM4ESMN1; SMN2BCL9CTNNB1 | |
| SCHEMBL2729880 | 0.81 | ALDH1A1 (0.45) | TDP1MAPTKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL15092197 | 0.80 | SLC1A3 (0.42) | TDP1MAPTKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL7549531 | 0.79 | TDP1 (0.49) | ATMTDP1RAPGEF3MAPTSMN1; SMN2 | |
| SCHEMBL6968807 | 0.79 | RAPGEF3 (0.53) | ATMTDP1RAPGEF3MAPTSMN1; SMN2 | |
| SCHEMBL25242510 | 0.79 | TDP1 (0.51) | ATMTDP1RAPGEF3MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252833-B2 | Benzo (f) isoindol-2-ylphenyl acetic acid derivatives as EP4 receptor agonists | GLAXO GROUP LIMITED (GB) | 2012-08-28 | — | — | US | disclosed |
| EP-1979316-B1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2012-07-11 | — | — | EP | disclosed |
| EP-2457897-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-05-30 | — | — | EP | disclosed |
| US-20100273853-A1 | NOVEL ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED | 2010-10-28 | — | — | US | disclosed |
| EP-2046742-B1 | BENZO [F] ISOINDOLES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2010-09-22 | — | — | EP | disclosed |
| US-20100069457-A1 | Naphthalene Derivatives Used As EP4 Receptor Agonists | GLAXO GROUP LIMITED (GB) | 2010-03-18 | — | — | US | disclosed |
| US-20090312388-A1 | Benzo [F] Isoindoles As EP4 Receptor Agonists | GLAXO GROUP LIMITED | 2009-12-17 | — | — | US | disclosed |
| EP-2051961-A1 | NOVEL ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2009-04-29 | — | — | EP | disclosed |
| EP-2049485-A1 | NAPHTHALENE DERIVATIVES USED AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2009-04-22 | — | — | EP | disclosed |
| EP-2046742-A1 | BENZO [F] ISOINDOLES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| WO-2009019281-A1 | BENZOISOINDOLE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR AGONISTS FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2009-02-12 | — | — | WO | disclosed |
| EP-1979316-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008020055-A1 | NOVEL ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008012344-A1 | NAPHTHALENE DERIVATIVES USED AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-01-31 | — | — | WO | disclosed |
| WO-2008012347-A1 | BENZO [F] ISOINDOLES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-01-31 | — | — | WO | disclosed |
| WO-2007088190-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312388-A1 | Benzo [F] Isoindoles As EP4 Receptor Agonists | PTGER4, GPR4, PTGER1 | ATM 3835/4885TDP1 4175/4885RAPGEF3 183/4885 |
| US-20100273853-A1 | NOVEL ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS | PTGER4, PTGER1, PTGER3 | ATM 2861/4885TDP1 3805/4885RAPGEF3 242/4885 |
| US-20100069457-A1 | Naphthalene Derivatives Used As EP4 Receptor Agonists | PTGER4, PTGER1, PTGER3 | ATM 3078/4885TDP1 4330/4885RAPGEF3 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.