Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2939980 | 0.85 | CTSD (0.37) | IGF1REPHX2PTGS2CYP3A4GAA | |
| SCHEMBL2939889 | 0.83 | IGF1R (0.32) | IGF1RMEN1KMT2A | |
| SCHEMBL2937249 | 0.82 | IGF1R (0.47) | IGF1RNAMPTARMEN1KMT2A | |
| SCHEMBL2940492 | 0.82 | IGF1R (0.42) | IGF1REPHX2MEN1KMT2A | |
| SCHEMBL2940341 | 0.80 | IGF1R (0.40) | IGF1RNAMPTMEN1KMT2ACYP2C19 | |
| SCHEMBL6173915 | 0.79 | IGF1R (0.41) | IGF1R | |
| SCHEMBL6173623 | 0.76 | IGF1R (0.38) | IGF1RNAMPTMEN1KMT2ACYP3A4 | |
| SCHEMBL2937313 | 0.68 | CACNA1G (0.41) | IGF1RNAMPTEPHX2PTGS2GAA | |
| SCHEMBL2938270 | 0.68 | ACACB (0.37) | — | |
| SCHEMBL6173451 | 0.68 | IGF1R (0.41) | IGF1RTRPV3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |