Harpagide

Harpagide

SCHEMBL29385820

C[C@]1(O)C[C@@H](O)[C@]2(O)C=CO[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]21

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.61
▸ TSHR P16473 1/20 0.61
▸ KDM4E B2RXH2 1/20 0.46
▸ GLA P06280 1/20 0.46
▸ CYP3A4 P08684 1/20 0.46
▸ POLB P06746 1/20 0.41
▸ CTDSP1 Q9GZU7 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ SYNJ2 O15056 2/20 0.40
▸ MEN1 O00255 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ HSP90AA1 P07900 2/20 0.39
▸ MAPT P10636 2/20 0.37
▸ PTPN1 P18031 2/20 0.37
▸ STAT3 P40763 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Harpagide SCHEMBL30132931 1.00 ALDH1A1 (0.61) ALDH1A1TSHRKDM4EGLACYP3A4
Harpagide SCHEMBL1425414 1.00 ALDH1A1 (0.61) ALDH1A1TSHRKDM4EGLACYP3A4
SCHEMBL29727271 0.84 ALDH1A1 (0.71) ALDH1A1TSHRKDM4EGLACYP3A4
SCHEMBL29208523 0.84 ALDH1A1 (0.71) ALDH1A1TSHRKDM4EGLACYP3A4
SCHEMBL29425887 0.84 ALDH1A1 (0.71) ALDH1A1TSHRKDM4EGLACYP3A4
SCHEMBL29425781 0.83 ALDH1A1 (0.49) ALDH1A1TSHRKDM4EGLACYP3A4
SCHEMBL422972 0.81 ALDH1A1 (0.53) ALDH1A1TSHRKDM4EGLACYP3A4
SCHEMBL9057878 0.80 ALDH1A1 (0.51) ALDH1A1TSHRKDM4EGLACYP3A4
Antirrhinoside SCHEMBL1424987 0.79 ALDH1A1 (0.51) ALDH1A1TSHRKDM4EGLACYP3A4
Antirrhinoside SCHEMBL27233579 0.79 ALDH1A1 (0.51) ALDH1A1TSHRKDM4EGLACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 — — EP claimed
EP-4379068-B1 IRIDOID OR SECO-IRIDOID DERIVATIVES AND THEIR USE IN A TANNING PROCESS INSTITUT NAT DES SCIENCES APPLIQUEES DE ROUEN (FR) 2025-06-04 — — EP claimed
WO-2023219526-A1 MULTITARGET ANTIVIRAL DIETARY SUPPLEMENT PROKIN MILAN (RS) 2023-11-16 — — WO claimed
EP-3319965-B1 NOVEL COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS (GR) 2022-05-04 — — EP claimed
CN-122056902-A Pharmaceutical application of harpagoside 金陵药业股份有限公司 2026-05-19 — — CN disclosed
EP-4525914-A1 METHODS OF SELECTIVELY TREATING TENDINOPATHY USING INTERLEUKIN-17 (IL-17) ANTAGONISTS Novartis AG (CH) 2025-03-26 — — EP disclosed
US-20240391886-A1 CARBON MONOXIDE PRODRUGS FOR THE TREATMENT OF MEDICAL DISORDERS GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2024-11-28 — — US disclosed
EP-3866773-B1 CARBON MONOXIDE PRODRUGS FOR THE TREATMENT OF MEDICAL DISORDERS UNIV GEORGIA STATE RES FOUND (US) 2024-08-28 — — EP disclosed
US-12071415-B2 Carbon monoxide prodrugs for the treatment of medical disorders GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2024-08-27 — — US disclosed
WO-2023223263-A1 METHODS OF SELECTIVELY TREATING TENDINOPATHY USING INTERLEUKIN-17 (IL-17) ANTAGONISTS NOVARTIS AG (CH) 2023-11-23 — — WO disclosed
WO-2023219526-A1 MULTITARGET ANTIVIRAL DIETARY SUPPLEMENT PROKIN MILAN (RS) 2023-11-16 — — WO disclosed
US-20230338315-A1 METHOD OF PRODUCING PHARMACEUTICAL COCRYSTALS FOR ADDITIVE MANUFACTURING BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-10-26 — — US disclosed
US-20230331834-A1 METHOD OF TREATING TENDINOPATHY USING INTERLEUKIN-17 (IL-17) NOVARTIS AG (CH) 2023-10-19 — — US disclosed
EP-4196111-A1 METHOD OF PRODUCING PHARMACEUTICAL COCRYSTALS FOR ADDITIVE MANUFACTURING Board of Regents, The University of Texas System (US) 2023-06-21 — — EP disclosed
WO-2022136344-A1 MODULATION OF PRDM12 FOR USE IN TREATMENT OF PAIN CONDITIONS Université Libre de Bruxelles (BE) 2022-06-30 — — WO disclosed
WO-2022036291-A9 METHOD OF PRODUCING PHARMACEUTICAL COCRYSTALS FOR ADDITIVE MANUFACTURING BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-04-21 — — WO disclosed
WO-2022036291-A1 METHOD OF PRODUCING PHARMACEUTICAL COCRYSTALS FOR ADDITIVE MANUFACTURING BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-02-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240391886-A1 CARBON MONOXIDE PRODRUGS FOR THE TREATMENT OF MEDICAL DISORDERS PYGL, HMOX2, MB ALDH1A1 976/4885TSHR 4002/4885KDM4E 2143/4885
US-12071415-B2 Carbon monoxide prodrugs for the treatment of medical disorders PYGL, HMOX2, MB ALDH1A1 976/4885TSHR 4002/4885KDM4E 2143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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