Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | APP | P05067 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.61 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.61 |
| ▸ | F7 | P08709 | 1/20 | 0.59 |
| ▸ | F3 | P13726 | 1/20 | 0.59 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.59 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.59 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.59 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.59 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2784997 | 0.87 | ALDH1A1 (0.71) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL30773490 | 0.83 | — | — | |
| SCHEMBL1414 | 0.83 | — | — | |
| SCHEMBL10860350 | 0.83 | ALDH1A1 (0.65) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL11799878 | 0.81 | ALDH1A1 (0.53) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL11799883 | 0.81 | ALDH1A1 (0.53) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL265578 | 0.81 | ALDH1A1 (0.69) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Hydrochloric Acid SCHEMBL61214 | 0.81 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL2690817 | 0.81 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 | |
| SCHEMBL3259196 | 0.81 | ALDH1A1 (0.69) | ALDH1A1APPGAAHCAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109983022-A | As the chromans of mGluR2 negativity allosteric modulators, heterochromatic full and dihydroisobenzofuran derivative, composition and application thereof | 默沙东公司 | 2019-07-05 | — | — | CN | disclosed |
| US-9051330-B2 | Dithiolopyrrolones with therapeutic activity | WELICHEM BIOTECH INC. (CA) | 2015-06-09 | — | — | US | disclosed |
| EP-2076519-B1 | NOVEL DITHIOLOPYRROLONES AND THEIR THERAPEUTICAL APPLICATIONS | CELESTIAL PHARMACEUTICALS SHENZHEN LTD (CN) | 2014-01-15 | — | — | EP | disclosed |
| US-8071637-B2 | Dithiolopyrrolones compounds and their therapeutic applications | WELICHEM BIOTECH INC. (CA) | 2011-12-06 | — | — | US | disclosed |
| CN-101522688-B | Dithiolopyrrolones and their therapeutic use | BEIJING WENFENG TIANJI MEDICINE TECHNOLOGY CO LTD | 2011-09-14 | — | — | CN | disclosed |
| EP-1490374-B1 | DITHIOLOPYRROLONE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISEASES | WELICHEM BIOTECH INC (CA) | 2010-09-22 | — | — | EP | disclosed |
| US-20100041729-A1 | DITHIOLOPYRROLONES COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | CELESTIAL PHARMACEUTICALS (SHENZHEN) LTD. (CN) | 2010-02-18 | — | — | US | disclosed |
| CN-101522688-A | Dithiolopyrrolones and their therapeutic use | CELESTIAL PHARMACEUTICALS SHEN (CN) | 2009-09-02 | — | — | CN | disclosed |
| EP-2076519-A2 | NOVEL DITHIOLOPYRROLONES AND THEIR THERAPEUTICAL APPLICATIONS | Celestial Pharmaceuticals (Shenzhen) LTD. (CN) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008038175-A2 | DITHIOLOPYRROLONES COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | CELESTIAL PHARMACEUTICALS (SHENZHEN) LTD. (CN) | 2008-04-03 | — | — | WO | disclosed |
| US-20060074125-A1 | Novel dithiolopyrrolones with therapeutic activity | WELICHEM BIOTECH INC. (CA) | 2006-04-06 | — | — | US | disclosed |
| EP-1490374-A2 | DITHIOLOPYRROLONE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISEASES | Welichem Biotech Inc. (CA) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080624-A2 | DITHIOLOPYRROLONE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISEASES | WELICHEM BIOTECH INC. (CA) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041729-A1 | DITHIOLOPYRROLONES COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | CD4, NDUFS3, TXN2 | ALDH1A1 728/4885APP 4476/4885GAA 4170/4885 |
| US-20060074125-A1 | Novel dithiolopyrrolones with therapeutic activity | TP53, DTYMK, MKI67 | ALDH1A1 749/4885APP 4569/4885GAA 2887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.