Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.38 |
| ▸ | CALCA | P06881 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25275576 | 1.00 | MAP4K1 (0.38) | MAP4K1CYP3A4OTUD7BCALCACDC7 | |
| SCHEMBL26167986 | 0.96 | MAP4K1 (0.38) | MAP4K1CYP3A4OTUD7BCALCACDC7 | |
| SCHEMBL31456439 | 0.96 | MAP4K1 (0.38) | MAP4K1CYP3A4OTUD7BCALCACDC7 | |
| SCHEMBL31212132 | 0.92 | OTUD7B (0.40) | MAP4K1CYP3A4OTUD7BCALCACYP1A2 | |
| SCHEMBL18181144 | 0.92 | OTUD7B (0.40) | MAP4K1CYP3A4OTUD7BCALCACYP1A2 | |
| SCHEMBL6002104 | 0.86 | ALDH1A1 (0.38) | CYP3A4OTUD7BCYP1A2SMN1; SMN2MAPK1 | |
| SCHEMBL31456368 | 0.85 | HTR2A (0.40) | CYP3A4OTUD7BCYP1A2 | |
| SCHEMBL20066175 | 0.83 | OTUD7B (0.40) | MAP4K1CYP3A4OTUD7BCALCASIGMAR1 | |
| SCHEMBL29709345 | 0.83 | OTUD7B (0.40) | MAP4K1CYP3A4OTUD7BCALCASIGMAR1 | |
| SCHEMBL10152976 | 0.82 | OTUD7B (0.42) | OTUD7BCALCASIGMAR1NPSR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4192957-A2 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| CN-116113698-A | TRPML modulators | 卡斯玛治疗公司 | 2023-05-12 | — | — | CN | disclosed |
| WO-2022032073-A2 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2022-02-10 | — | — | WO | disclosed |