Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.36 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31456354 | 0.90 | HTR2A (0.37) | HTR2AALDH1A1CYP3A4HSD17B10CYP1A2 | |
| SCHEMBL31456439 | 0.85 | MAP4K1 (0.38) | HTR2ACYP3A4CYP1A2OTUD7BHTR2C | |
| SCHEMBL25275576 | 0.85 | MAP4K1 (0.38) | CYP3A4CYP1A2OTUD7B | |
| SCHEMBL26167986 | 0.85 | MAP4K1 (0.38) | HTR2ACYP3A4CYP1A2OTUD7BHTR2C | |
| SCHEMBL29386972 | 0.85 | MAP4K1 (0.38) | CYP3A4CYP1A2OTUD7B | |
| SCHEMBL6002104 | 0.82 | ALDH1A1 (0.38) | HTR2AALDH1A1CYP3A4HSD17B10CYP1A2 | |
| SCHEMBL31212132 | 0.81 | OTUD7B (0.40) | CYP3A4CYP1A2OTUD7B | |
| SCHEMBL18181144 | 0.81 | OTUD7B (0.40) | CYP3A4CYP1A2OTUD7B | |
| SCHEMBL30277974 | 0.76 | HTR2A (0.46) | HTR2AALDH1A1CYP3A4HSD17B10CYP1A2 | |
| SCHEMBL20066175 | 0.73 | OTUD7B (0.40) | CYP3A4CYP1A2OTUD7B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12208088-B2 | Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof | GENENTECH, INC. (US) | 2025-01-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12208088-B2 | Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof | HIPK1, NEK1, HIPK2 | HTR2A 2524/4885ALDH1A1 2398/4885CYP3A4 3696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.