Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945939 | 0.85 | MAPT (0.36) | ALDH1A1KMT2AGAAMAPTTHRB | |
| SCHEMBL2938724 | 0.82 | WDR5 (0.47) | WDR5ALDH1A1LMNAKMT2AGAA | |
| SCHEMBL3301272 | 0.76 | BACE1 (0.39) | POLB | |
| SCHEMBL398803 | 0.73 | ALDH1A1 (0.61) | WDR5ALDH1A1LMNAKMT2AGAA | |
| SCHEMBL30410222 | 0.73 | ALDH1A1 (0.61) | WDR5ALDH1A1LMNAKMT2AGAA | |
| SCHEMBL4277663 | 0.71 | MAPT (0.41) | ALDH1A1LMNAKMT2AMAPTMEN1 | |
| SCHEMBL21590163 | 0.69 | LMNA (0.63) | WDR5ALDH1A1LMNAKMT2AGAA | |
| SCHEMBL30198175 | 0.67 | ALDH1A1 (0.71) | WDR5ALDH1A1LMNAKMT2AGAA | |
| SCHEMBL854050 | 0.67 | ALDH1A1 (0.71) | WDR5ALDH1A1LMNAKMT2AGAA | |
| SCHEMBL9300572 | 0.67 | ALDH1A1 (0.58) | WDR5ALDH1A1LMNAKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |