Magainin I

Magainin I

SCHEMBL29392863

CC[C@H](C)[C@H](NC(=O)CN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)CC)C(C)C

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ CALCR P30988 4/20 0.59
▸ BACE1 P56817 1/20 0.57
▸ CRHR1 P34998 1/20 0.57
▸ CRHR2 Q13324 1/20 0.57
▸ RXFP1 Q9HBX9 1/20 0.56
▸ KEAP1 Q14145 1/20 0.55
▸ GLP1R P43220 6/20 0.53
▸ PTH1R Q03431 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Magainin 2 SCHEMBL29357968 0.97 CALCR (0.63) CALCRBACE1CRHR1CRHR2RXFP1
SCHEMBL29633610 0.97 CALCR (0.63) CALCRBACE1CRHR1CRHR2RXFP1
SCHEMBL29949418 0.91 CALCR (0.64) CALCRBACE1CRHR1CRHR2RXFP1
SCHEMBL31438606 0.91 TFPI (0.54) CALCRGLP1R
SCHEMBL30633102 0.91 PTH1R (0.61) BACE1RXFP1GLP1RPTH1R
SCHEMBL30262006 0.89 GLP1R (0.52) CALCRCRHR1CRHR2RXFP1GLP1R
SCHEMBL30262193 0.89 PTH1R (0.64) CALCRRXFP1KEAP1GLP1RPTH1R
SCHEMBL30658366 0.89 CALCR (0.60) CALCRCRHR1CRHR2RXFP1KEAP1
SCHEMBL30432434 0.88 CALCR (0.66) CALCRBACE1CRHR1CRHR2GLP1R
SCHEMBL30524353 0.87 GLP1R (0.48) CALCRRXFP1GLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025018943-A1 BIODEGRADABLE POLYION COMPLEX NANOPARTICLES OF CATIONIC ANTIMICROBIALS FOR ACTIVATABLE ANTIBACTERIAL THERAPY NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2025-01-23 — — WO claimed
US-11725227-B2 Devices and methods for examining drug effects on microorganisms ESSENLIX CORPORATION (US) 2023-08-15 — — US claimed
CN-114748692-B Mesoporous silica-based surface-functionalized titanium-based implant, and preparation method and application thereof 华南理工大学 2023-06-20 — — CN claimed
CN-110927372-B Colorimetric immunosensor based on double nano-composites and preparation method and application thereof 军事科学院军事医学研究院军事兽医研究所 2022-12-06 — — CN claimed
CN-114748692-A Surface functionalized titanium-based implant based on mesoporous silica and preparation method and application thereof 华南理工大学 2022-07-15 — — CN claimed
CN-110531075-B Pathogenic bacteria immunoassay biosensor based on antibacterial peptide-phosphate nano compound and preparation method and application thereof 军事科学院军事医学研究院军事兽医研究所 2022-06-14 — — CN claimed
US-12577602-B2 Compositions and methods for peptide production BIOCATALYST LLC (US) 2026-03-17 — — US disclosed
EP-3574909-B1 POLYELECTROLYTE MULTILAYER COMPRISING SILVER FOR WOUND HEALING IMBED BIOSCIENCES INC (US) 2026-03-04 — — EP disclosed
US-20260000805-A1 METHODS AND COMPOSITIONS FOR WOUND HEALING IMBED BIOSCIENCES INC (US) 2026-01-01 — — US disclosed
US-20250375394-A1 METHODS AND COMPOSITIONS FOR MODIFYING MUCOUS MEMBRANES ABBOTT NICHOLAS L (US) 2025-12-11 — — US disclosed
EP-4626479-A1 COMPOSITIONS AND METHODS FOR PROTEIN INTERNALIZATION Lytica Therapeutics, Inc. (US) 2025-10-08 — — EP disclosed
US-RE50618-E1 Anionic-core composition for delivery of therapeutic agents, and methods of making and using the same PHARMAIN CORPORATION (US) 2025-10-07 — — US disclosed
US-12409247-B2 Methods and compositions for wound healing IMBED BIOSCIENCES INC. (US) 2025-09-09 — — US disclosed
EP-3983428-A1 DE NOVO DESIGN OF PHOSPHORYLATION INDUCIBLE PROTEIN SWITCHES (PHOSPHO-SWITCHES) University of Washington (US) 2022-04-20 — — EP disclosed
CN-114302895-A Novel design of phosphorylation-induced protein switch (phosphate switch) 华盛顿大学 2022-04-08 — — CN disclosed
WO-2022069996-A1 BIODEGRADABLE POLYMER AND SOLVENT COMPOSITIONS AND SYSTEMS FOR EXTENDED STORAGE AND DELIVERY OF ACTIVE PHARMACEUTICAL INGREDIENTS TOLMAR INTERNATIONAL LIMITED (IE) 2022-04-07 — — WO disclosed
US-20220073565-A1 DE NOVO DESIGN OF PROTEIN SWITCHES FOR TUNABLE CONTROL OF PROTEIN DEGRADATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-03-10 — — US disclosed
WO-2022048733-A1 METHOD FOR PRODUCING MACROPOROUS SCAFFOLDS COMPOSED OF SILK AND CALCIUM PHOSPHATE SPIBER TECHNOLOGIES AB (SE) 2022-03-10 — — WO disclosed
CN-109655609-B Platinum-nanoflower and preparation method and application thereof 军事科学院军事医学研究院军事兽医研究所 2022-03-01 — — CN disclosed
CN-114053481-A Preparation method of titanium-based bone dental implant material loaded with antibacterial polypeptide and antibacterial ions 广东省华源康泰生物科技有限责任公司 2022-02-18 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12577602-B2 Compositions and methods for peptide production LNPEP, CPN1, PRCP CALCR 278/4885BACE1 153/4885CRHR1 405/4885
US-20260000805-A1 METHODS AND COMPOSITIONS FOR WOUND HEALING PCNA, ARG1, PLOD3 CALCR 2540/4885BACE1 4523/4885CRHR1 4344/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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