Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 5/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19640460 | 1.00 | TRPV1 (0.36) | TRPV1EGFRNR3C1AURKARPS6KB1 | |
| SCHEMBL17501512 | 0.89 | NR3C1 (0.36) | TRPV1EGFRNR3C1AURKARPS6KB1 | |
| SCHEMBL19640385 | 0.87 | KIF11 (0.41) | TRPV1EGFRNR3C1AURKARPS6KB1 | |
| SCHEMBL29400051 | 0.87 | KIF11 (0.41) | TRPV1EGFRNR3C1AURKARPS6KB1 | |
| SCHEMBL19640436 | 0.85 | PTK2 (0.38) | EGFRAURKARPS6KB1AURKBLMNA | |
| SCHEMBL19640398 | 0.84 | EGFR (0.40) | EGFRAURKARPS6KB1AURKBLMNA | |
| SCHEMBL19650884 | 0.82 | TRPV1 (0.36) | TRPV1CYP3A4USP2CYP1A2CYP2D6 | |
| SCHEMBL19640698 | 0.82 | VNN1 (0.40) | EGFRAURKARPS6KB1AURKBLMNA | |
| SCHEMBL29400234 | 0.82 | VNN1 (0.40) | EGFRAURKARPS6KB1AURKBLMNA | |
| SCHEMBL19640424 | 0.80 | PPARA (0.39) | EGFRAURKARPS6KB1AURKBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11254681-B2 | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases | NUEVOLUTION A/S (DK) | 2022-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11254681-B2 | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases | PPARD, PPARG, RORC | TRPV1 1594/4885EGFR 1169/4885NR3C1 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.