Sugi Predict

Sugi Predict / Compounds / SCHEMBL294059

SCHEMBL294059

SCHEMBL294059

O=Cc1cc(Cl)cc(Cl)c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ERN1 O75460 7/20 1.00
▸ ALDH1A1 P00352 4/20 0.56
▸ CYP3A4 P08684 2/20 0.56
▸ TSHR P16473 2/20 0.56
▸ RECQL P46063 2/20 0.56
▸ HSD17B10 Q99714 2/20 0.56
▸ TDP1 Q9NUW8 1/20 0.50
▸ MEN1 O00255 5/20 0.47
▸ KMT2A Q03164 5/20 0.47
▸ MAPT P10636 3/20 0.47
▸ KDM4E B2RXH2 2/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.47
▸ AKR1C4 P17516 1/20 0.47
▸ AKR1C3 P42330 1/20 0.47
▸ AKR1C2 P52895 1/20 0.47
▸ AKR1C1 Q04828 1/20 0.47
▸ CA1 P00915 2/20 0.45
▸ CA2 P00918 2/20 0.45
▸ CA12 O43570 1/20 0.45
▸ CA9 Q16790 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29382880 1.00 ERN1 (1.00) ERN1ALDH1A1CYP3A4TSHRRECQL
SCHEMBL30294924 0.98 ERN1 (0.96) ERN1ALDH1A1CYP3A4TSHRRECQL
SCHEMBL27998889 0.98 ERN1 (0.96) ERN1ALDH1A1CYP3A4TSHRRECQL
SCHEMBL28337241 0.98 ERN1 (0.96) ERN1ALDH1A1CYP3A4TSHRRECQL
Bicarbonate SCHEMBL8193408 0.90 ERN1 (0.81) ERN1ALDH1A1CYP3A4TSHRRECQL
Bicarbonate SCHEMBL8193406 0.90 ERN1 (0.81) ERN1ALDH1A1CYP3A4TSHRRECQL
SCHEMBL27854738 0.90 ERN1 (0.81) ERN1ALDH1A1CYP3A4TSHRRECQL
SCHEMBL6093685 0.88 ERN1 (1.00) ERN1ALDH1A1CYP3A4TSHRRECQL
Salicyladehyde SCHEMBL28644176 0.86 ERN1 (0.73) ERN1ALDH1A1CYP3A4TSHRRECQL
Pyridine SCHEMBL28196948 0.86 ERN1 (0.73) ERN1ALDH1A1CYP3A4TSHRRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1265 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12503449-B2 Methods of preparing chiral benzodiazepinone derivatives IMMUNOME, INC. (US) 2025-12-23 — — US claimed
US-20250346565-A1 METHODS OF PREPARING CHIRAL BENZODIAZEPINONE DERIVATIVES AYALA PHARMACEUTICALS INC. 2025-11-13 — — US claimed
WO-2025005863-A2 MICROREACTOR, SYSTEM AND METHOD FOR INVESTIGATING A SOLID-FLUID CHEMICAL REACTION IN A MICROREACTOR PAEBBL AB (SE) 2025-01-02 — — WO claimed
CN-118304271-A Cell membrane bionic co-delivery system based on oxidative stress and excitotoxicity double-target combination and preparation method thereof 江阴市人民医院 2024-07-09 — — CN claimed
CN-117820329-A Spiropyran derivative and synthetic method and application thereof 陕西科技大学 2024-04-05 — — CN claimed
CN-117586433-A N, N, N-trimethyl chitosan quaternary ammonium salt containing glycine Schiff base and preparation and application thereof 中国科学院烟台海岸带研究所 2024-02-23 — — CN claimed
CN-117534625-A Sulfite fluorescent probe and preparation method and application thereof 无锡学院 2024-02-09 — — CN claimed
CN-117264220-A Preparation method of Co (II) coordination polymer bacteriostat 鲁东大学 2023-12-22 — — CN claimed
CN-117209741-A Preparation method of Schiff base catalyst and preparation method of polyglycolic acid 中国科学院长春应用化学研究所 2023-12-12 — — CN claimed
CN-117143274-A Catalyst composition, olefin polymerization process and use 中国石油化工股份有限公司 2023-12-01 — — CN claimed
US-5986107-A Process for the preparation of a 2-oxopyrrolidine compound G. D. SEARLE & CO. (US) 1999-11-16 — — US claimed
WO-1999051573-A2 PROCESS FOR THE PREPARATION OF A 2-OXOPYRROLIDINE COMPOUND G.D. SEARLE & CO. (US) 1999-10-14 — — WO claimed
US-5496955-A RESOLUTION OF ISOMERS BY REACTION WITH ALDEHYDE IN ACETIC ACID AND TARTARIC ACID BROMINE COMPOUNDS LIMITED (IL) 1996-03-05 — — US claimed
US-4861727-A Luminescent oxygen sensor based on a lanthanide complex C. R. BARD, INC. (US) 1989-08-29 — — US claimed
EP-0253571-B1 PROCESS FOR RESOLUTION AND RACE MIZATION OF AMINES WITH ACIDIC ALPHA-HYDROGENS MERCK & CO. INC. (US) 1989-08-23 — — EP claimed
US-4859771-A Process for resolution and racemization of amines with acidic α-hydrogens MERCK & CO., INC. (US) 1989-08-22 — — US claimed
EP-0259951-A2 Luminescent oxygen sensor based on a lanthanide complex C.R. BARD, INC. (US) 1988-03-16 — — EP claimed
EP-0253571-A1 Process for resolution and race mization of amines with acidic alpha-hydrogens MERCK & CO. INC. (US) 1988-01-20 — — EP claimed
US-4661636-A 6-sulfoxyphenol derivatives, their preparation and their use as cytoprotective agents HOECHST AKTIENGESELLSCHAFT (DE) 1987-04-28 — — US claimed
EP-0135860-A2 Derivatives of 6-sulfoxyphenol, their preparation and their use as cytoprotectors; use of derivatives of salicylaldehyde as cytoprotectors HOECHST AKTIENGESELLSCHAFT (DE) 1985-04-03 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12503449-B2 Methods of preparing chiral benzodiazepinone derivatives CHRNA1, CHRM1, ME1 ERN1 4132/4885ALDH1A1 190/4885CYP3A4 575/4885
US-20250346565-A1 METHODS OF PREPARING CHIRAL BENZODIAZEPINONE DERIVATIVES ADH5, CHRNA1, GABRB3 ERN1 4317/4885ALDH1A1 188/4885CYP3A4 596/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.