Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22659077 | 1.00 | KMT2A (0.42) | KMT2AATMMLYCDCES2TRPM8 | |
| SCHEMBL5654548 | 0.88 | KMT2A (0.51) | KMT2AATMMLYCDCES2TRPM8 | |
| SCHEMBL16648653 | 0.84 | KMT2A (0.52) | KMT2AATMCES2HCRTR1HCRTR2 | |
| SCHEMBL156712 | 0.84 | NOTUM (0.42) | KMT2AMLYCDCES2MAPTNOTUM | |
| SCHEMBL4007735 | 0.81 | CES2 (0.53) | KMT2AMLYCDCES2TRPM8MAPT | |
| SCHEMBL8575500 | 0.80 | LMNA (0.49) | MLYCDSMN1; SMN2MAOBEPHX2 | |
| SCHEMBL25298572 | 0.78 | ALDH1A1 (0.45) | KMT2AMLYCDCES2TRPM8CLK1 | |
| SCHEMBL5636266 | 0.78 | MEN1 (0.41) | KMT2AMLYCDCES2TRPM8MAPT | |
| SCHEMBL2472646 | 0.78 | KEAP1 (0.54) | MLYCDCES2TRPM8MAPTCLK1 | |
| SCHEMBL696154 | 0.78 | NOTUM (0.51) | CES2HCRTR1HCRTR2NOTUMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966208-A2 | COMPOUNDS AND METHODS FOR TREATING CANCER | Antidote IP Holdings, LLC (US) | 2022-03-16 | — | — | EP | disclosed |