Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphine SCHEMBL1067622 | 0.83 | — | — | |
| SCHEMBL1798747 | 0.80 | — | — | |
| Tromethamine SCHEMBL5988271 | 0.77 | LMNA (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL4939766 | 0.77 | LMNA (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL1508805 | 0.77 | LMNA (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL28672604 | 0.76 | MEN1 (0.50) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL8507166 | 0.74 | MEN1 (0.48) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL11143695 | 0.72 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL60850 | 0.71 | CA1 (0.52) | — | |
| Tromethamine SCHEMBL6427079 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281311-A2 | Phosphine oxide process | Albright & Wilson Limited (GB) | 1988-09-07 | — | — | EP | claimed |
| US-9750258-B2 | Stable composition for controlling biological growth and method for using same in oil field applications | LONZA INC. (US) | 2017-09-05 | — | — | US | disclosed |
| EP-2707376-B1 | METHODS FOR CONTROLLING DEPOLYMERIZATION OF POLYMER COMPOSITIONS | RHODIA OPERATIONS (FR) | 2016-11-30 | — | — | EP | disclosed |
| EP-3057416-A1 | STABLE COMPOSITION FOR CONTROLLING BIOLOGICAL GROWTH AND METHOD FOR USING SAME IN OIL FIELD APPLICATIONS | Lonza Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057401-A1 | STABLE COMPOSITION FOR CONTROLLING BIOLOGICAL GROWTH AND METHOD FOR USING SAME IN OIL FIELD APPLICATIONS | LONZA INC. (US) | 2015-04-23 | — | — | WO | disclosed |
| US-20150105353-A1 | Stable Composition For Controlling Biological Growth and Method For Using Same in Oil Field Applications | Arxada, LLC | 2015-04-16 | — | — | US | disclosed |
| EP-2396170-B1 | METHODS FOR CONTROLLING DEPOLYMERIZATION OF POLYMER COMPOSITIONS | RHODIA OPERATIONS (FR) | 2015-03-25 | — | — | EP | disclosed |
| WO-2010093473-A1 | METHODS FOR CONTROLLING DEPOLYMERIZATION OF POLYMER COMPOSITIONS | RHODIA OPERATIONS (FR) | 2010-08-19 | — | — | WO | disclosed |
| US-4673509-A | ADDING PHOSPHONIUM COMPOUND | ALBRIGHT & WILSON LIMITED (GB) | 1987-06-16 | — | — | US | disclosed |
| EP-0139404-A1 | Biocidal water treatment | Albright & Wilson Limited (GB) | 1985-05-02 | — | — | EP | disclosed |