Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL11881550 | 0.96 | MEN1 (0.83) | — | |
| Tromethamine SCHEMBL17484 | 0.95 | MEN1 (1.00) | — | |
| Tromethamine SCHEMBL3696191 | 0.95 | — | — | |
| Tromethamine SCHEMBL975 | 0.95 | — | — | |
| Tromethamine SCHEMBL2035496 | 0.91 | — | — | |
| Tromethamine SCHEMBL2263148 | 0.91 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL445853 | 0.91 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL7091147 | 0.91 | — | — | |
| Tromethamine SCHEMBL8379571 | 0.91 | — | — | |
| Tromethamine SCHEMBL7068977 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115200954-A | Method for reducing saliva viscosity and application thereof | 珠海大略科技有限公司 | 2022-10-18 | — | — | CN | claimed |
| JP-55094950-A | — | — | None | — | — | JP | disclosed |
| CN-112210027-B | Precursor polymer of cleavable material, cleavable material and preparation method thereof | 苏州永沁泉智能设备有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-115200954-A | Method for reducing saliva viscosity and application thereof | 珠海大略科技有限公司 | 2022-10-18 | — | — | CN | disclosed |
| US-6913720-B2 | Non-woven fabric with flame retardant properties and method of making same | RAPONI ANTHONY S (CA) | 2005-07-05 | — | — | US | disclosed |
| US-20030114070-A1 | Non-woven fabric with flame retardant properties and method of making same | RAPONI ANTHONY S (CA) | 2003-06-19 | — | — | US | disclosed |
| JP-S5594950-A | PHOSPHOROUS TRIS*ORTHOALKYLPHENYL* ESTER | BORG WARNER | 1980-07-18 | — | — | JP | disclosed |