Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of Pyrrolidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HTR6 | P50406 | 8/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperidine SCHEMBL3747941 | 0.98 | SMN1; SMN2 (0.64) | TSHRSMN1; SMN2HTR6POLBCYP2D6 | |
| Azetidine SCHEMBL28177662 | 0.96 | TSHR (0.73) | TSHRSMN1; SMN2HTR6POLBCYP2D6 | |
| Piperazine SCHEMBL1589534 | 0.91 | TSHR (0.73) | TSHRSMN1; SMN2HTR6POLBCYP2D6 | |
| Cyclohexane SCHEMBL18585697 | 0.84 | TSHR (0.84) | TSHRSMN1; SMN2HTR6POLBCYP2D6 | |
| Cyclopropane SCHEMBL2101078 | 0.84 | TSHR (0.84) | TSHRSMN1; SMN2HTR6POLBCYP2D6 | |
| SCHEMBL8374928 | 0.84 | TSHR (0.94) | TSHRSMN1; SMN2HTR6POLBCYP2D6 | |
| Morpholine SCHEMBL3328086 | 0.82 | TSHR (0.59) | TSHRSMN1; SMN2HTR6POLBCYP2D6 | |
| SCHEMBL22283832 | 0.82 | TSHR (0.59) | TSHRSMN1; SMN2HTR6POLBCYP2D6 | |
| Phosphine SCHEMBL27770571 | 0.82 | TSHR (0.80) | TSHRSMN1; SMN2HTR6POLBCYP2D6 | |
| SCHEMBL2509 | 0.82 | TSHR (1.00) | TSHRSMN1; SMN2HTR6POLBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101911229-A | Electric double layer capacitor | SHOWA DENKO KK | 2010-12-08 | — | — | CN | disclosed |
| US-20100296226-A1 | ELECTRIC DOUBLE LAYER CAPACITOR | SHOWA DENKO K.K. (JP) | 2010-11-25 | — | — | US | disclosed |