Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.34 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039209 | 1.00 | CXCR3 (0.38) | CXCR3CCR5KMT2AL3MBTL1PLA2G10 | |
| SCHEMBL4037623 | 0.88 | KMT2A (0.40) | CCR5KMT2AL3MBTL1STSNPFFR1 | |
| SCHEMBL2943021 | 0.88 | KMT2A (0.40) | CCR5KMT2AL3MBTL1STSNPFFR1 | |
| SCHEMBL1801457 | 0.86 | OPRD1 (0.47) | CXCR3CCR5STSOPRD1OPRK1 | |
| SCHEMBL3919286 | 0.86 | OPRD1 (0.47) | CXCR3CCR5STSOPRD1OPRK1 | |
| SCHEMBL4035453 | 0.82 | BCHE (0.47) | KMT2A | |
| SCHEMBL1797763 | 0.79 | CYP2D6 (0.51) | CXCR3CCR5KMT2AOPRD1OPRK1 | |
| SCHEMBL4037006 | 0.79 | KMT2A (0.35) | KMT2APLA2G10PLA2G5STS | |
| SCHEMBL1801100 | 0.79 | CXCR3 (0.39) | CXCR3CCR5KMT2A | |
| SCHEMBL2932612 | 0.79 | KMT2A (0.35) | KMT2APLA2G10PLA2G5STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730147-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2010-02-03 | — | — | EP | disclosed |
| WO-2005095402-A9 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2009-06-11 | — | — | WO | disclosed |
| EP-1730147-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005095402-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2005-10-13 | — | — | WO | disclosed |