Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 6/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.32 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2943021 | 1.00 | KMT2A (0.40) | KMT2AGAATSHRCCR5L3MBTL1 | |
| SCHEMBL4035139 | 0.89 | GAA (0.43) | KMT2AGAATSHRCCR5CACNA1G | |
| SCHEMBL2940834 | 0.88 | CXCR3 (0.38) | KMT2ACCR5L3MBTL1STSNPFFR1 | |
| SCHEMBL4039209 | 0.88 | CXCR3 (0.38) | KMT2ACCR5L3MBTL1STSNPFFR1 | |
| SCHEMBL1800888 | 0.88 | OPRD1 (0.44) | KMT2AGAACCR5STSOPRD1 | |
| SCHEMBL3919263 | 0.88 | OPRD1 (0.44) | KMT2AGAACCR5STSOPRD1 | |
| SCHEMBL3918968 | 0.82 | GAA (0.46) | KMT2AGAATSHRCCR5CACNA1G | |
| SCHEMBL4035046 | 0.81 | GAA (0.35) | KMT2AGAACCR5CACNA1G | |
| SCHEMBL4037470 | 0.81 | GAA (0.44) | KMT2AGAATSHRCCR5L3MBTL1 | |
| SCHEMBL4035369 | 0.80 | GAA (0.42) | KMT2AGAATSHRCCR5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | disclosed |
| EP-1730144-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5|DECAN-2-ONE COMPOUNDS | Grünenthal GmbH (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005095398-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ONE COMPOUNDS | Grünenthal GmbH (DE) | 2005-10-13 | — | — | WO | disclosed |