Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL21582175 | 1.00 | MAOB (0.56) | MAOBABCB1MEN1KMT2ABCHE | |
| Bromide SCHEMBL16897957 | 0.93 | MEN1 (0.50) | MAOBMEN1KMT2ABCHEAPP | |
| Bromide SCHEMBL1164751 | 0.89 | TSHR (0.46) | MAOBABCB1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL5973630 | 0.86 | TSHR (0.46) | MAOBABCB1TSHRMAPK1 | |
| SCHEMBL23906959 | 0.83 | MAOB (0.79) | MAOBABCB1MEN1KMT2ABCHE | |
| Bromide SCHEMBL17385989 | 0.81 | TACR1 (0.51) | MAOBTSHRMAPK1 | |
| Bromide SCHEMBL3110986 | 0.80 | TAAR1 (0.56) | MAOBABCB1HTR1ADRD2 | |
| Bromide SCHEMBL4362183 | 0.79 | LMNA (0.55) | MAOBBCHE | |
| SCHEMBL16551002 | 0.79 | MAOB (0.67) | MAOBABCB1MEN1KMT2ABCHE | |
| SCHEMBL31208272 | 0.79 | TAAR1 (0.57) | MAOBABCB1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3968976-A1 | PHENANTHRENE AMPK ACTIVATOR COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF | Société des Produits Nestlé S.A. (CH) | 2022-03-23 | — | — | EP | disclosed |
| US-20220062199-A1 | PHENANTHRENE AMPK ACTIVATOR COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF | NESTLE SA (CH) | 2022-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220062199-A1 | PHENANTHRENE AMPK ACTIVATOR COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF | PRKAG2, PRKAG1, PRKAG3 | MAOB 3790/4885ABCB1 2602/4885MEN1 2856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.