Clobetasone Butyrate

Clobetasone Butyrate

SCHEMBL29410388

CCCC(=O)O[C@]1(C(=O)CCl)[C@H](C)C[C@@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@]3(F)C(=O)C[C@@]21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 4/20 1.00
▸ MAPT P10636 3/20 1.00
▸ SMN1; SMN2 Q16637 2/20 1.00
▸ NPSR1 Q6W5P4 2/20 1.00
▸ CYP3A4 P08684 6/20 0.69
▸ PGR P06401 6/20 0.69
▸ USP2 O75604 5/20 0.69
▸ NR3C1 P04150 5/20 0.69
▸ NR1I2 O75469 2/20 0.69
▸ CYP2D6 P10635 2/20 0.69
▸ CYP2C9 P11712 2/20 0.69
▸ MLNR O43193 1/20 0.69
▸ ABCB11 O95342 1/20 0.69
▸ CYP3A5 P20815 1/20 0.69
▸ PPARG P37231 1/20 0.69
▸ MEN1 O00255 1/20 0.63
▸ KMT2A Q03164 1/20 0.63
▸ ADORA3 P0DMS8 3/20 0.57
▸ DRD2 P14416 1/20 0.57
▸ OPRD1 P41143 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Clobetasone Butyrate SCHEMBL11750078 1.00 LMNA (1.00) LMNAMAPTSMN1; SMN2NPSR1CYP3A4
Clobetasone Butyrate SCHEMBL36599 1.00 LMNA (1.00) LMNAMAPTSMN1; SMN2NPSR1CYP3A4
Clobetasone Butyrate SCHEMBL29572705 1.00 LMNA (1.00) LMNAMAPTSMN1; SMN2NPSR1CYP3A4
Clobetasone Butyrate SCHEMBL11124627 1.00 LMNA (1.00) LMNAMAPTSMN1; SMN2NPSR1CYP3A4
Clobetasone Butyrate SCHEMBL448850 1.00 LMNA (1.00) LMNAMAPTSMN1; SMN2NPSR1CYP3A4
Clobetasone Butyrate SCHEMBL14339619 1.00 LMNA (1.00) LMNAMAPTSMN1; SMN2NPSR1CYP3A4
SCHEMBL732359 0.96 LMNA (0.92) LMNAMAPTSMN1; SMN2NPSR1CYP3A4
SCHEMBL568167 0.94 LMNA (0.88) LMNAMAPTSMN1; SMN2NPSR1CYP3A4
SCHEMBL28099304 0.94 LMNA (0.88) LMNAMAPTSMN1; SMN2NPSR1CYP3A4
SCHEMBL11748908 0.93 LMNA (0.87) LMNAMAPTSMN1; SMN2NPSR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 — — WO claimed
EP-3943073-B1 BIODEGRADABLE POLYMER MICROPARTICLE CONTAINING STEROID-BASED DRUG AND PREPARATION METHOD THEREFOR REGENBIOTECH INC (KR) 2025-03-26 — — EP claimed
EP-4178579-B1 5-AMINO-2,3-DIHYDRO-1,4-PHTHALAZINEDIONE AS GLUCOCORTICOID-SPARING AGENT METRIOPHARM AG (CH) 2025-02-12 — — EP claimed
EP-3682872-B1 LIQUISOFT CAPSULES PATHEON SOFTGELS INC (US) 2024-01-03 — — EP claimed
EP-4013420-B1 METHOD OF BLOCKING OR AMELIORATING CYTOKINE RELEASE SYNDROME RIGEL PHARMACEUTICALS INC (US) 2023-11-01 — — EP claimed
EP-3407890-B1 PHARMACEUTICAL PREPARATION AND THE USE THEREOF FOR TREATING VIRAL LARYNGITIS SOMMER PETER (DE) 2023-07-19 — — EP claimed
EP-3068437-B2 SPRAYABLE TOPICAL CARRIER AND COMPOSITION COMPRISING PHOSPHATIDYLCHOLINE LIPIDOR AB (SE) 2022-07-06 — — EP claimed
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 — — WO disclosed
US-12533372-B2 Biological polysaccharide for preventing and treating acne and steroid- dependent dermatitis and use thereof Boman (Zhejiang) Biotechnology Co., Ltd. (CN) 2026-01-27 — — US disclosed
US-20250381192-A1 Treatment of Autoimmune Disease JAK SLAVE PTY LTD (AU) 2025-12-18 — — US disclosed
US-12364696-B2 Treatment of autoimmune disease JAK SLAVE PTY LTD (AU) 2025-07-22 — — US disclosed
US-20250213572-A1 TYK2 INHIBITORS AND USES THEREOF NIMBUS DISCOVERY, INC. 2025-07-03 — — US disclosed
WO-2025088039-A1 HIGHLY CONCENTRATED DERMALLY APPLICABLE PERMETHRIN PREPARATION WITH AN INCREASED DRUG LOAD IN THE TARGET COMPARTMENT FOR IMPROVED TREATMENT OF ECTOPARASITE INFESTATION INFECTOPHARM ARZNEIMITTEL UND CONSILIUM GMBH (DE) 2025-05-01 — — WO disclosed
EP-3407890-B1 PHARMACEUTICAL PREPARATION AND THE USE THEREOF FOR TREATING VIRAL LARYNGITIS SOMMER PETER (DE) 2023-07-19 — — EP disclosed
EP-4034086-A1 FORMULATION HEWLETT HEALTHCARE LIMITED (GB) 2022-08-03 — — EP disclosed
CN-108341739-B Preparation method of alpha-aryl, heteroaryl or alkenyl-alpha, alpha-difluoromethyl compound 中国科学院上海有机化学研究所 2022-07-19 — — CN disclosed
US-20220143025-A1 TREATMENT OF AUTOIMMUNE DISEASE JAK SLAVE PTY LTD (AU) 2022-05-12 — — US disclosed
US-20220105064-A1 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER BIOGEN SWISS MFG GMBH (CH) 2022-04-07 — — US disclosed
WO-2022059618-A1 COAT-FORMING AEROSOL COMPOSITION AND AEROSOL TYPE COAT-FORMING TOPICAL FORMULATION 久光製薬株式会社 2022-03-24 — — WO disclosed
WO-2022050376-A1 DRUG DELIVERY METHOD USING LIGHT, AND TARGET ACCUMULATION TYPE COMPLEX 国立大学法人東海国立大学機構 2022-03-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12364696-B2 Treatment of autoimmune disease JAK1, JAK3, JAK2 LMNA 4676/4885MAPT 2566/4885SMN1; SMN2 4724/4885
US-20250381192-A1 Treatment of Autoimmune Disease JAK1, JAK3, JAK2 LMNA 4676/4885MAPT 2566/4885SMN1; SMN2 4724/4885
US-20250213572-A1 TYK2 INHIBITORS AND USES THEREOF TYK2, JAK1, JAK2 LMNA 1873/4885MAPT 589/4885SMN1; SMN2 3626/4885
US-12533372-B2 Biological polysaccharide for preventing and treating acne and steroid- dependent dermatitis and use thereof CYP17A1, SHBG, CUTA LMNA 3215/4885MAPT 3973/4885SMN1; SMN2 4879/4885
US-20220143025-A1 TREATMENT OF AUTOIMMUNE DISEASE JAK1, JAK3, JAK2 LMNA 4676/4885MAPT 2566/4885SMN1; SMN2 4724/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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