Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.69 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.69 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.63 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.45 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.45 |
| ▸ | CHRNG | P07510 | 1/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRND | Q07001 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5912286 | 1.00 | CHRNB2 (0.69) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL30711273 | 0.85 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL16272028 | 0.85 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| Hydrochloric Acid SCHEMBL17667438 | 0.84 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| Hydrochloric Acid SCHEMBL27806813 | 0.83 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL159642 | 0.82 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL7008708 | 0.82 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL31465048 | 0.82 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL30676152 | 0.79 | CYP11B2 (0.67) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL533875 | 0.79 | CYP11B2 (0.67) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250163443-A1 | METHODS FOR PRODUCING LOW-NICOTINE TOBACCO | UNIV NORTH CAROLINA STATE (US) | 2025-05-22 | — | — | US | disclosed |
| US-20250043298-A1 | INCREASING ANATABINE IN TOBACCO LEAF BY REGULATING METHYL PUTRESCINE OXIDASE | PHILIP MORRIS PRODUCTS S.A. (CH) | 2025-02-06 | — | — | US | disclosed |
| US-20240368615-A1 | MODULATING ALKALOID PROFILES IN NICOTIANA TABACUM | PHILIP MORRIS PRODUCTS S.A. (CH) | 2024-11-07 | — | — | US | disclosed |
| US-12084670-B2 | Regulating alkaloids | 22ND CENTURY LIMITED, LLC (US) | 2024-09-10 | — | — | US | disclosed |
| US-12018265-B2 | Nucleic acid encoding n-methylputrescine oxidase and uses thereof | 22ND CENTURY LIMITED, LLC (US) | 2024-06-25 | — | — | US | disclosed |
| WO-2023141481-A9 | METHODS FOR PRODUCING LOW-NICOTINE TOBACCO | NORTH CAROLINA STATE UNIVERSITY (US) | 2024-05-23 | — | — | WO | disclosed |
| US-20230399652-A1 | INCREASING LEVELS OF NICOTINIC ALKALOIDS IN PLANTS | 22ND CENTURY LIMITED, LLC (US) | 2023-12-14 | — | — | US | disclosed |
| US-11839231-B2 | Reducing levels of nicotinic alkaloids in plants | 22ND CENTURY LIMITED, LLC (US) | 2023-12-12 | — | — | US | disclosed |
| US-20230340510-A1 | REGULATING ALKALOIDS | 22ND CENTURY LIMITED, LLC (US) | 2023-10-26 | — | — | US | disclosed |
| US-20230340514-A1 | NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM | 22ND CENTURY LIMITED, LLC (US) | 2023-10-26 | — | — | US | disclosed |
| US-11667924-B2 | Increasing levels of nicotinic alkaloids in plants | 22ND CENTURY LIMITED, LLC (US) | 2023-06-06 | — | — | US | disclosed |
| WO-2023036691-A1 | MODULATING ALKALOID PROFILES IN NICOTIANA TABACUM | PHILIP MORRIS PRODUCTS S.A. (CH) | 2023-03-16 | — | — | WO | disclosed |
| US-11597941-B2 | Nucleic acid sequences encoding transcription factors regulating alkaloid biosynthesis and their use in modifying plant metabolism | 22ND CENTURY LIMITED, LLC (US) | 2023-03-07 | — | — | US | disclosed |
| US-20230048978-A1 | NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM | 22ND CENTURY LIMITED, LLC (US) | 2023-02-16 | — | — | US | disclosed |
| US-11572568-B2 | Regulating alkaloids | 22ND CENTURY LIMITED, LLC (US) | 2023-02-07 | — | — | US | disclosed |
| US-20230029030-A1 | NUCLEIC ACID ENCODING N-METHYLPUTRESCINE OXIDASE AND USES THEREOF | 22ND CENTURY LIMITED, LLC (US) | 2023-01-26 | — | — | US | disclosed |
| US-20220275387-A1 | TRANSCRIPTION FACTOR NtERF221 AND METHODS OF USING THE SAME | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2022-09-01 | — | — | US | disclosed |
| US-11396656-B2 | Nucleic acid encoding n-methylputrescine oxidase and uses thereof | 22ND CENTURY LIMITED, LLC (US) | 2022-07-26 | — | — | US | disclosed |
| EP-4009777-A1 | TRANSCRIPTION FACTOR NTERF221 AND METHODS OF USING THE SAME | University Of Virginia Patent Foundation (US) | 2022-06-15 | — | — | EP | disclosed |
| US-20220087306-A1 | REDUCING LEVELS OF NICOTINIC ALKALOIDS IN PLANTS | 22ND CENTURY LIMITED, LLC (US) | 2022-03-24 | — | — | US | disclosed |