SCHEMBL29411421

SCHEMBL29411421

O=c1[nH]c2ccc(S(=O)(=O)NCCCc3ccc(-c4ccccc4F)cc3)cc2o1

nearest known ligand 0.56

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.52
ALPL P05186 2/20 0.52
ALPI P09923 1/20 0.52
ALPG P10696 1/20 0.52
POLB P06746 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21045164 1.00 KMT2A (0.52) KMT2AALPLALPIALPGPOLB
SCHEMBL21045290 0.76 MEN1 (0.62) KMT2AALPLALPIALPG
SCHEMBL29411536 0.76 MEN1 (0.62) KMT2AALPLALPIALPG
SCHEMBL21045101 0.74 ALDH1A1 (0.51) KMT2A
SCHEMBL29411527 0.74 ALDH1A1 (0.51) KMT2A
SCHEMBL12633839 0.73 KMT2A (0.72) KMT2AALPLALPIALPGPOLB
SCHEMBL21045103 0.72 PKM (0.66) KMT2APOLB
SCHEMBL29411450 0.72 PKM (0.66) KMT2APOLB
SCHEMBL21045147 0.69 GRIA4 (0.48) KMT2A
SCHEMBL29411437 0.69 GRIA4 (0.48) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250188035-A1 TUBULIN INHIBITORS LIN BIOSCIENCE LLC (US) 2025-06-12 US disclosed
US-12247010-B2 Tubulin inhibitors LIN BIOSCIENCE INC. (TW) 2025-03-11 US disclosed
US-20220089539-A1 TUBULIN INHIBITORS LIN BIOSCIENCE INC. (TW) 2022-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220089539-A1 TUBULIN INHIBITORS TUBB3, TUBB1, TUBB KMT2A 2339/4885ALPL 3620/4885ALPI 3765/4885
US-12247010-B2 Tubulin inhibitors TUBB3, TUBB1, TUBB KMT2A 2339/4885ALPL 3620/4885ALPI 3765/4885
US-20250188035-A1 TUBULIN INHIBITORS TUBB3, TUBB1, TUBB KMT2A 2339/4885ALPL 3620/4885ALPI 3765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.