Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | IDH2 | P48735 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.55 |
| ▸ | YAP1 | P46937 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064881 | 1.00 | MAPT (1.00) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL1921484 | 0.88 | MAPT (0.77) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL6295118 | 0.87 | MAPT (0.77) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL28465275 | 0.86 | MAPT (0.76) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL7166997 | 0.82 | MAPT (0.75) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL20693799 | 0.81 | ALDH1A1 (0.69) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL21856308 | 0.81 | MAPT (0.68) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL29824523 | 0.81 | MAPT (0.68) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL11566545 | 0.81 | ALDH1A1 (0.68) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL15875869 | 0.81 | MAPT (0.68) | MAPTALDH1A1GAARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220402869-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-12-22 | — | — | US | disclosed |
| CN-111747933-B | Substituted 1,3, 5-triazine compound, composition and application thereof | 吉林省元合电子材料有限公司 | 2022-03-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402869-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | TEAD1, TEAD4, TEAD2 | MAPT 342/4885ALDH1A1 2662/4885GAA 4225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.