Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18366875 | 1.00 | HDAC1 (0.48) | HDAC1HDAC6MAPTNOTUMKMT2A | |
| SCHEMBL1414421 | 0.87 | KLKB1 (0.50) | HDAC1HDAC6NOTUMSMN1; SMN2KLKB1 | |
| SCHEMBL18366907 | 0.85 | RAB9A (0.48) | HDAC1HDAC6MAPTNOTUMKMT2A | |
| SCHEMBL18366896 | 0.85 | L3MBTL1 (0.47) | HDAC1HDAC6MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL30587599 | 0.85 | L3MBTL1 (0.47) | HDAC1HDAC6MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL18366879 | 0.84 | HDAC1 (0.49) | HDAC1HDAC6MAPTTP53CACNA1G | |
| SCHEMBL30092734 | 0.84 | HDAC1 (0.49) | HDAC1HDAC6MAPTTP53CACNA1G | |
| SCHEMBL24311065 | 0.83 | KDM4E (0.52) | HDAC1HDAC6KMT2ASMN1; SMN2LMNA | |
| SCHEMBL19224666 | 0.82 | RIPK1 (0.52) | — | |
| SCHEMBL29415736 | 0.82 | RIPK1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |