Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28305102 | 0.75 | PTGDR2 (0.48) | ALDH1A1HPGDSMN1; SMN2PTGDR2MEN1 | |
| SCHEMBL29375816 | 0.71 | CYP2D6 (0.42) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL29644614 | 0.69 | PTPN1 (0.38) | — | |
| SCHEMBL19943971 | 0.67 | ABCB1 (0.45) | PTGDR2MEN1KMT2A | |
| SCHEMBL28420979 | 0.67 | POLB (0.36) | ALDH1A1HPGDMEN1KMT2AGAA | |
| SCHEMBL30788667 | 0.67 | RXRA (0.40) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL29897446 | 0.66 | CYP2D6 (0.49) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3148621 | 0.66 | PTGDR2 (0.47) | ALDH1A1PTGDR2MEN1KMT2ACYP2D6 | |
| SCHEMBL15635353 | 0.66 | CYP2D6 (0.49) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL196223 | 0.66 | CA12 (0.68) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117062809-A | Bicyclic heterocyclic FGFR4 inhibitors, pharmaceutical compositions and formulations comprising the same and uses thereof | 杭州普洛药物研究院有限公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-110709392-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-116751199-A | Mitochondrial protease targeted chimera, preparation method and application | 中国科学院基础医学与肿瘤研究所(筹) | 2023-09-15 | — | — | CN | disclosed |
| CN-116731016-A | Tricyclic heterocyclic compounds as IAP antagonists | 苏州亚盛药业有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-111566101-B | CDK4/6 inhibitors and pharmaceutically acceptable salts and polymorphs thereof and uses thereof | 上海海雁医药科技有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-116234809-A | Methods of preparing alpha-1 antitrypsin modulators | 弗特克斯药品有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-116113626-A | Compound with anti-tumor activity and application thereof | 上海翊石医药科技有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-113166163-B | 7- (methylamino) pyrazolo [1,5-A ] pyrimidine-3-carboxamide derivatives | 伊莱利利公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-115768764-A | Fused ring compound with anti-tumor activity and application thereof | 上海翊石医药科技有限公司 | 2023-03-07 | — | — | CN | disclosed |
| CN-110545817-B | GSK-3 inhibitors | 百时美施贵宝公司 | 2022-11-15 | — | — | CN | disclosed |
| CN-115038705-A | 7- (methylamino) pyrazolo [1,5-a ] pyrimidine-3-carboxamide compounds | 伊莱利利公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-114656464-A | 6,7,8, 9-tetrahydro-3H-pyrazolo [4,3-f ] isoquinoline derivatives useful for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2022-06-24 | — | — | CN | disclosed |
| US-20220135536-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2022-05-05 | — | — | US | disclosed |
| CN-110167946-B | Sulfonamide compounds having TNAP inhibitory activity | 第一三共株式会社 | 2022-04-08 | — | — | CN | disclosed |
| CN-109843888-B | 6, 7, 8, 9-tetrahydro-3H-pyrazolo [4, 3-f ] isoquinoline derivatives useful for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2022-03-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220135536-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | DHODH, DHPS, DPYD | ALDH1A1 132/4885HPGD 28/4885SMN1; SMN2 4116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.