Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28420979 | 0.79 | POLB (0.36) | MEN1GAAKMT2AALDH1A1HPGD | |
| SCHEMBL30576990 | 0.76 | POLB (0.36) | MEN1GAAKMT2AALDH1A1HPGD | |
| SCHEMBL29015609 | 0.71 | — | — | |
| SCHEMBL27007938 | 0.70 | HPGD (0.33) | MEN1GAAKMT2AHPGDRAB9A | |
| SCHEMBL29416152 | 0.67 | ALDH1A1 (0.43) | HTTMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL30762275 | 0.66 | RXRA (0.48) | RXRARXRBWDR5GABRA1GABRG2 | |
| SCHEMBL18733762 | 0.66 | FAAH (0.43) | RXRARXRBFAAHMEN1KMT2A | |
| SCHEMBL29644614 | 0.66 | PTPN1 (0.38) | — | |
| SCHEMBL8469211 | 0.65 | RXRA (0.72) | RXRARXRBGABRA1GABRG2GABRB3 | |
| SCHEMBL2968363 | 0.64 | RXRA (0.53) | RXRARXRBGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117510463-A | KIF18A inhibitor compound, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-02-06 | — | — | CN | disclosed |