Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3828857 | 0.76 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2MAPTNPSR1KDM4E | |
| SCHEMBL1094685 | 0.74 | APOBEC3G (0.47) | ALDH1A1NPSR1HSD17B10KMT2AGAA | |
| SCHEMBL15884499 | 0.74 | NR1I2 (0.44) | ALDH1A1SMN1; SMN2NPSR1HPGDHSD17B10 | |
| SCHEMBL3467600 | 0.74 | APOBEC3G (0.39) | ALDH1A1NPSR1HSD17B10KMT2AGAA | |
| SCHEMBL3581609 | 0.72 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2MAPTNPSR1KDM4E | |
| SCHEMBL1093933 | 0.70 | KDM4E (0.49) | ALDH1A1KDM4EHSD17B10KMT2AGAA | |
| SCHEMBL10953409 | 0.70 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2MAPTNPSR1KDM4E | |
| SCHEMBL5138358 | 0.68 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPTNPSR1KDM4E | |
| SCHEMBL27970004 | 0.68 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2MAPTNPSR1KDM4E | |
| SCHEMBL8759387 | 0.68 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2MAPTNPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240474-B1 | CYCLIC PYRIDYL-N-(1,3,4)-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2012-03-14 | — | — | EP | disclosed |
| EP-2240474-A1 | CYCLIC PYRIDYL-N-(1,3,4)-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2010-10-20 | — | — | EP | disclosed |