Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | PER2 | O15055 | 1/20 | 0.39 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.39 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16177880 | 0.83 | APOBEC3G (0.48) | ALDH1A1SMN1; SMN2APOBEC3GPKMPER2 | |
| SCHEMBL3581609 | 0.70 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2APOBEC3GPKMESR1 | |
| SCHEMBL3828857 | 0.70 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2APOBEC3GPKMESR1 | |
| SCHEMBL294183 | 0.68 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2APOBEC3GPKMKMT2A | |
| SCHEMBL31338952 | 0.68 | HTR6 (0.50) | ALDH1A1SMN1; SMN2PKMKMT2AHSD17B10 | |
| SCHEMBL10584541 | 0.68 | HTR6 (0.50) | ALDH1A1SMN1; SMN2PKMKMT2AHSD17B10 | |
| SCHEMBL27986016 | 0.68 | PKM (0.50) | ALDH1A1SMN1; SMN2APOBEC3GPKMESR1 | |
| SCHEMBL5138358 | 0.68 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2APOBEC3GKMT2AHSD17B10 | |
| SCHEMBL812682 | 0.68 | PKM (0.79) | ALDH1A1SMN1; SMN2APOBEC3GPKMESR1 | |
| SCHEMBL28994882 | 0.67 | ALDH1A1 (0.37) | ALDH1A1PER2CRY1CRY2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104093716-A | Biaryl ether sulfonamides and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2014-10-08 | — | — | CN | claimed |
| CN-104024251-A | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC | 2014-09-03 | — | — | CN | claimed |
| CN-104093716-A | Biaryl ether sulfonamides and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2014-10-08 | — | — | CN | disclosed |
| CN-104024251-A | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC | 2014-09-03 | — | — | CN | disclosed |