Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29587495 | 0.80 | DAO (0.51) | RIPK1DAOHRH4HRH3 | |
| SCHEMBL29602065 | 0.79 | RIPK1 (0.51) | RIPK1DAOHRH4HRH3 | |
| SCHEMBL29588892 | 0.79 | RIPK1 (0.52) | RIPK1DAOHRH4HRH3 | |
| SCHEMBL30568660 | 0.78 | HSD17B10 (0.54) | SMN1; SMN2HSD17B10KDM4EALDH1A1TP53 | |
| SCHEMBL832252 | 0.78 | KDM4E (0.58) | SMN1; SMN2RIPK1HSD17B10KDM4EALDH1A1 | |
| SCHEMBL170083 | 0.77 | HSD17B10 (0.56) | SMN1; SMN2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL1939638 | 0.76 | DRD2 (0.50) | RIPK1DAOMAPT | |
| SCHEMBL3380080 | 0.76 | HSD17B10 (0.65) | SMN1; SMN2HSD17B10KDM4EALDH1A1TP53 | |
| SCHEMBL29765495 | 0.75 | RIPK1 (0.44) | RIPK1DAOHRH4HRH3 | |
| SCHEMBL253780 | 0.75 | ALDH1A1 (0.54) | RIPK1KDM4EALDH1A1HTTDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110724142-B | Amide or sulfonamide substituted hydrazine derivatives as JAK kinase inhibitors | 启元生物(杭州)有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-114685505-A | Imidazopyrrolopyridines as JAK family kinase inhibitors | 詹森药业有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-114478528-A | Aroyl-substituted tricyclic compound, preparation method and application thereof | 劲方医药科技(上海)有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-110312719-B | Imidazopyrrolopyridines as JAK family kinase inhibitors | 詹森药业有限公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-110088105-B | Small molecule inhibitors of JAK family kinases | 詹森药业有限公司 | 2022-03-18 | — | — | CN | disclosed |