Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2941530 | 0.87 | HPGD (0.43) | TSHRSMN1; SMN2POLBNPSR1KMT2A | |
| SCHEMBL1801112 | 0.83 | CRBN (0.45) | CRBNHTTCYP2C19TSHRSMN1; SMN2 | |
| SCHEMBL2940806 | 0.83 | CA1 (0.56) | — | |
| SCHEMBL2934834 | 0.83 | NPC1 (0.48) | HTTTSHRALOX15MAPTNPSR1 | |
| SCHEMBL2942653 | 0.82 | HPGD (0.42) | HTTTSHRPOLBMAPTNPSR1 | |
| SCHEMBL2940005 | 0.81 | MGLL (0.43) | HTTCYP2C19TSHRSMN1; SMN2KMT2A | |
| SCHEMBL2943558 | 0.80 | ALDH1A1 (0.50) | SMN1; SMN2POLBNPSR1KMT2A | |
| SCHEMBL2934172 | 0.79 | CYP2C9 (0.53) | HTTCYP2C19TSHRSMN1; SMN2KMT2A | |
| SCHEMBL2943001 | 0.79 | MEN1 (0.39) | CYP2C19TSHRKMT2A | |
| SCHEMBL1801302 | 0.78 | RIPK1 (0.47) | CYP2C19TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730147-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2010-02-03 | — | — | EP | claimed |