Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12024903 | 0.90 | KDM4E (0.56) | ALDH1A1SMN1; SMN2POLBHTTNPSR1 | |
| SCHEMBL12024915 | 0.90 | PDE4A (0.47) | ALDH1A1SMN1; SMN2POLBHTTNPSR1 | |
| SCHEMBL11436470 | 0.86 | KDM4E (0.62) | ALDH1A1SMN1; SMN2POLBHTTNPSR1 | |
| SCHEMBL12251439 | 0.85 | KDM4E (0.53) | ALDH1A1SMN1; SMN2POLBHTTHSD17B10 | |
| SCHEMBL12251438 | 0.85 | KDM4E (0.53) | ALDH1A1SMN1; SMN2POLBHTTHSD17B10 | |
| SCHEMBL22820476 | 0.84 | KDM4E (0.47) | ALDH1A1SMN1; SMN2POLBHTTNPSR1 | |
| SCHEMBL6671333 | 0.84 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2POLBHTTNPSR1 | |
| SCHEMBL22276350 | 0.84 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2POLBHTTNPSR1 | |
| SCHEMBL19155962 | 0.83 | KDM4E (0.46) | ALDH1A1SMN1; SMN2POLBHTTNPSR1 | |
| SCHEMBL24467929 | 0.82 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2POLBHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0926119-A1 | Dialkoxybenzene electron donors | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1999-06-30 | — | — | EP | claimed |
| US-10689381-B2 | Vinblastine 20″ amides: synthetic analogs that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-06-23 | — | — | US | disclosed |
| US-20190119277-A1 | VINBLASTINE 20' AMIDES: SYNTHETIC ANALOGS THAT MAINTAIN OR IMPROVE POTENCY AND SIMULTANEOUSLY OVERCOME Pgp-DERIVED EFFLUX AND RESISTANCE | THE SCRIPPS RESEARCH INSTITUTE | 2019-04-25 | — | — | US | disclosed |
| CN-104193857-A | SELF-LIMITING CATALYST COMPOSITION WITH BIDENTATE INTERNAL DONOR | DOW GLOBAL TECHNOLOGIES INC | 2014-12-10 | — | — | CN | disclosed |
| CN-101945897-B | Self-limiting catalyst composition with bidentate internal donors | DOW GLOBAL TECHNOLOGIES INC | 2014-08-20 | — | — | CN | disclosed |
| CN-101945897-A | Self-limiting catalyst composition with bidentate internal donors | DOW GLOBAL TECHNOLOGIES INC (US) | 2011-01-12 | — | — | CN | disclosed |
| US-20100273641-A1 | Self-Limiting Catalyst Composition with Non-Phthalate Internal Donor | W. R. GRACE & CO.-CONN. | 2010-10-28 | — | — | US | disclosed |
| EP-2225288-A1 | SELF-LIMITING CATALYST COMPOSITION WITH BIDENTATE INTERNAL DONOR | Dow Global Technologies Inc. (US) | 2010-09-08 | — | — | EP | disclosed |
| US-20090291945-A1 | CYSTEINE PROTEASE INHIBITORS | TEIJIN PHARMA LIMITED (JP) | 2009-11-26 | — | — | US | disclosed |
| WO-2009085649-A1 | SELF-LIMITING CATALYST COMPOSITION WITH BIDENTATE INTERNAL DONOR | DOW GLOBAL TECHNOLOGIES INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| EP-0922712-B1 | Novel electron donor containing compositions | UNION CARBIDE CHEM PLASTIC (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6399837-B1 | POLYMERIZATION CATALYST FOR OLEFINS | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION | 2002-06-04 | — | — | US | disclosed |
| US-6124507-A | USED IN THE MANUFACTURE OF OLEFIN POLYMERIZATION CATALYSTS WITH PROCATALYSTS HAVING MAGNESIUM, TITANIUM AND HALIDE AS ESSENTIAL COMPONENTS. 1-ETHOXY-2-ALKOXY-4,5,6-OPTIONALLY SUBSTITUTED BENZENES | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 2000-09-26 | — | — | US | disclosed |
| US-5968865-A | COORDINATION CATALYST COMPRISING MAGNESIUM, TITANIUM, HALIDE, AND 1,2-DIALKOXYBENZENE COMPOUNDS; OLEFIN POLYMERIZATION CATALYSTS | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0926119-A1 | Dialkoxybenzene electron donors | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0922712-A1 | Novel electron donor containing compositions | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1999-06-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291945-A1 | CYSTEINE PROTEASE INHIBITORS | CTSE, SPINT2, CTSF | ALDH1A1 2506/4885SMN1; SMN2 4525/4885POLB 4172/4885 |
| US-10689381-B2 | Vinblastine 20″ amides: synthetic analogs that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance | ABCG2, ABCC1, GLS | ALDH1A1 633/4885SMN1; SMN2 1963/4885POLB 386/4885 |
| US-20190119277-A1 | VINBLASTINE 20' AMIDES: SYNTHETIC ANALOGS THAT MAINTAIN OR IMPROVE POTENCY AND SIMULTANEOUSLY OVERCOME Pgp-DERIVED EFFLUX AND RESISTANCE | ABCG2, ABCC1, GLS | ALDH1A1 642/4885SMN1; SMN2 1998/4885POLB 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.