Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 1.00 |
| ▸ | RET | P07949 | 5/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 2/20 | 1.00 |
| ▸ | FLT1 | P17948 | 2/20 | 1.00 |
| ▸ | EPHB2 | P29323 | 2/20 | 1.00 |
| ▸ | CDK2 | P24941 | 1/20 | 1.00 |
| ▸ | PIK3R1 | P27986 | 1/20 | 1.00 |
| ▸ | KIF5B | P33176 | 1/20 | 1.00 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 1.00 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.97 |
| ▸ | RAF1 | P04049 | 4/20 | 0.77 |
| ▸ | BRAF | P15056 | 3/20 | 0.77 |
| ▸ | EGFR | P00533 | 11/20 | 0.77 |
| ▸ | SRC | P12931 | 3/20 | 0.75 |
| ▸ | GAK | O14976 | 2/20 | 0.74 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.74 |
| ▸ | STK10 | O94804 | 1/20 | 0.74 |
| ▸ | FLT3 | P36888 | 1/20 | 0.74 |
| ▸ | JAK3 | P52333 | 1/20 | 0.74 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30249695 | 1.00 | KDR (1.00) | KDRRETFGFR1FLT1EPHB2 | |
| SCHEMBL1180103 | 1.00 | KDR (1.00) | KDRRETFGFR1FLT1EPHB2 | |
| Hydrochloric Acid SCHEMBL30433676 | 0.99 | NOD1 (1.00) | KDRRETFGFR1FLT1EPHB2 | |
| SCHEMBL5565577 | 0.88 | FGFR1 (0.78) | KDRRETFGFR1FLT1EPHB2 | |
| SCHEMBL15052582 | 0.87 | BRAF (1.00) | KDRRETFGFR1FLT1EPHB2 | |
| SCHEMBL31060707 | 0.86 | EGFR (1.00) | KDRRETFGFR1FLT1EPHB2 | |
| SCHEMBL5482883 | 0.86 | EGFR (1.00) | KDRRETFGFR1FLT1EPHB2 | |
| SCHEMBL5474772 | 0.86 | KDR (1.00) | KDRRETFGFR1FLT1EPHB2 | |
| SCHEMBL5569018 | 0.86 | KDR (1.00) | KDRRETFGFR1FLT1EPHB2 | |
| SCHEMBL15051582 | 0.85 | BRAF (1.00) | KDRRETFGFR1FLT1EPHB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12351571-B2 | Substituted quinoxaline compounds as inhibitors of FGFR tyrosine kinases | ARRAY BIOPHARMA INC. (US) | 2025-07-08 | — | — | US | disclosed |
| US-20220081438-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES | ARRAY BIOPHARMA INC. | 2022-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220081438-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES | FGFR1, FGFR4, FGFR3 | KDR 91/4885RET 11/4885FGFR1 1/4885 |
| US-12351571-B2 | Substituted quinoxaline compounds as inhibitors of FGFR tyrosine kinases | FGFR3, FGFR4, FGFR1 | KDR 253/4885RET 38/4885FGFR1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.