Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 1/20 | 0.65 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1052487 | 0.79 | F11 (1.00) | F11CA12CA9POLBKMT2A | |
| SCHEMBL5518679 | 0.79 | SRD5A2 (0.61) | KMT2AMEN1NPC1RAB9ASRD5A2 | |
| SCHEMBL29356704 | 0.78 | CA12 (0.55) | F11CA12CA9SRD5A2MAPK1 | |
| SCHEMBL1050811 | 0.78 | CA12 (0.55) | F11CA12CA9SRD5A2MAPK1 | |
| SCHEMBL6706696 | 0.78 | AHR (0.59) | KMT2ANPC1RAB9ASRD5A2MAPK1 | |
| SCHEMBL9475353 | 0.77 | SRD5A2 (0.59) | KMT2AMEN1NPC1RAB9ASRD5A2 | |
| SCHEMBL5758311 | 0.77 | LMNA (0.47) | F11KMT2AMEN1SRD5A2MAPK1 | |
| SCHEMBL3793284 | 0.77 | CA12 (0.58) | F11CA12CA9MAPK1CA1 | |
| SCHEMBL5792615 | 0.77 | CA12 (0.53) | F11CA12CA9MAPK1CHEK2 | |
| SCHEMBL2324527 | 0.77 | F11 (0.73) | F11CA12CA9POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230089412-A1 | METHODS OF TREATING CANCER PATIENTS WITH FARNESYLTRANSFERASE INHIBITORS | KURA ONCOLOGY INC (US) | 2023-03-23 | — | — | US | disclosed |
| US-20220143006-A1 | METHODS OF TREATING CANCER WITH FARNESYLTRANSFERASE INHIBITORS | KURA ONCOLOGY, INC. | 2022-05-12 | — | — | US | disclosed |
| EP-3995589-A1 | METHODS OF TREATING CANCER PATIENTS WITH FARNESYL TRANSFERASE INHIBITORS | Kura Oncology, Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| CN-114306604-A | Use of farnesyl transferase inhibitors for the treatment of cancer | 库拉肿瘤学公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-110325212-B | Farnesyl transferase inhibitors for use in methods of treating cancer | 库拉肿瘤学公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-114107497-A | Use of farnesyl transferase inhibitors for the treatment of cancer | 库拉肿瘤学公司 | 2022-03-01 | — | — | CN | disclosed |