Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 11/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CASR | P41180 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24324217 | 1.00 | PLK1 (0.60) | PLK1HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL24324038 | 0.80 | PLK1 (0.66) | PLK1 | |
| SCHEMBL29446327 | 0.80 | PLK1 (0.66) | PLK1 | |
| SCHEMBL24324052 | 0.79 | PLK1 (0.64) | PLK1MEN1KMT2A | |
| SCHEMBL7415598 | 0.76 | ALDH1A1 (0.57) | PLK1HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL24324738 | 0.75 | PLK1 (1.00) | PLK1 | |
| SCHEMBL29446338 | 0.75 | PLK1 (1.00) | PLK1 | |
| SCHEMBL6395824 | 0.74 | PLA2G2A (0.46) | PLK1MEN1KMT2A | |
| SCHEMBL6215775 | 0.73 | MMP13 (0.47) | PLK1HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL6229879 | 0.71 | MMP13 (0.55) | PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4216958-A2 | PLK1 POLO BOX DOMAIN INHIBITORS AND METHOD OF TREATING CANCER | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022067100-A2 | PLK1 POLO BOX DOMAIN INHIBITOR AND METHOD OF TREATING CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-03-31 | — | — | WO | disclosed |