Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29446347 | 0.76 | PLK1 (0.60) | PLK1MEN1KMT2AHDAC1HDAC11 | |
| SCHEMBL24324217 | 0.76 | PLK1 (0.60) | PLK1MEN1KMT2AHDAC1HDAC11 | |
| SCHEMBL6212062 | 0.76 | MMP13 (0.49) | MAPTKDM4E | |
| SCHEMBL6850020 | 0.76 | MEN1 (0.48) | ALDH1A1PLK1MAPTKDM4EHTT | |
| SCHEMBL6395824 | 0.76 | PLA2G2A (0.46) | ALDH1A1PLK1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6215775 | 0.74 | MMP13 (0.47) | ALDH1A1PLK1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL24324894 | 0.72 | PLK1 (1.00) | ALDH1A1PLK1 | |
| SCHEMBL20989143 | 0.72 | ALDH1A1 (0.85) | ALDH1A1PLK1TP53MAPTKDM4E | |
| SCHEMBL6229879 | 0.72 | MMP13 (0.55) | ALDH1A1PLK1MAPTKDM4EHTT | |
| SCHEMBL6428012 | 0.72 | PLK1 (0.40) | ALDH1A1PLK1MAPTKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002543199-A | — | — | 2002-12-17 | — | — | JP | claimed |
| EP-1177195-A1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER-LAMBERT COMPANY (US) | 2002-02-06 | — | — | EP | claimed |
| WO-2000066584-A1 | 1-AMINO TRIAZOLO¢4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER-LAMBERT COMPANY (US) | 2000-11-09 | — | — | WO | claimed |