Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | MPO | P05164 | 9/20 | 0.58 |
| ▸ | XDH | P47989 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | PRNP | P04156 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24324387 | 0.74 | PLK1 (1.00) | PLK1 | |
| SCHEMBL2730488 | 0.73 | MPO (1.00) | MPOXDHMEN1KMT2ARXFP1 | |
| SCHEMBL2732033 | 0.72 | MPO (1.00) | PLK1MPOXDHMEN1KMT2A | |
| SCHEMBL15549239 | 0.70 | MPO (1.00) | MPOXDHMEN1KMT2ARXFP1 | |
| SCHEMBL31160837 | 0.67 | FEN1 (0.57) | MPOXDHMEN1KMT2AFEN1 | |
| SCHEMBL2730994 | 0.66 | XDH (0.62) | MPOXDHMEN1KMT2AALDH1A1 | |
| SCHEMBL23045531 | 0.66 | ALDH1A1 (0.71) | MPOXDHMEN1KMT2ARXFP1 | |
| SCHEMBL29446368 | 0.66 | MPO (0.57) | PLK1MPOXDHMEN1KMT2A | |
| SCHEMBL26655709 | 0.66 | MPO (0.57) | PLK1MPOXDHMEN1KMT2A | |
| SCHEMBL26655708 | 0.66 | MPO (0.67) | PLK1MPOXDHMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4216958-A2 | PLK1 POLO BOX DOMAIN INHIBITORS AND METHOD OF TREATING CANCER | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022067100-A2 | PLK1 POLO BOX DOMAIN INHIBITOR AND METHOD OF TREATING CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-03-31 | — | — | WO | disclosed |