Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | MPO | P05164 | 6/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15537894 | 0.79 | ALDH1A1 (0.73) | XDHALDH1A1MPOL3MBTL1MAPT | |
| SCHEMBL2730470 | 0.77 | XDH (1.00) | XDHALDH1A1MPOL3MBTL1HPGD | |
| SCHEMBL20079373 | 0.71 | ALDH1A1 (0.44) | XDHALDH1A1MPOL3MBTL1HPGD | |
| SCHEMBL2730707 | 0.68 | MPO (1.00) | XDHALDH1A1MPOL3MBTL1KMT2A | |
| SCHEMBL16844164 | 0.68 | MPO (0.70) | XDHALDH1A1MPOL3MBTL1HPGD | |
| SCHEMBL2966714 | 0.67 | PGR (0.66) | PGR | |
| SCHEMBL29446444 | 0.66 | PLK1 (0.59) | XDHALDH1A1MPOL3MBTL1KMT2A | |
| SCHEMBL6401448 | 0.65 | MPO (0.70) | XDHALDH1A1MPOPDE7APDE7B | |
| SCHEMBL6668697 | 0.65 | CA9 (0.59) | XDHALDH1A1MPOHPGDPGR | |
| SCHEMBL20079368 | 0.65 | ALDH1A1 (0.47) | XDHALDH1A1L3MBTL1HPGDPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150110723-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2015-04-23 | — | — | US | claimed |
| WO-2013181135-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-12-05 | — | — | WO | claimed |
| EP-2632466-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | Emory University (US) | 2013-09-04 | — | — | EP | claimed |
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-08-29 | — | — | US | claimed |
| WO-2012058211-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2012-05-03 | — | — | WO | claimed |
| US-9868728-B2 | Quinazoline derivatives, compositions, and uses related thereto | EMORY UNIVERSITY (US) | 2018-01-16 | — | — | US | disclosed |
| EP-2886120-A1 | Quinazoline derivatives, compositions and uses related thereto | Emory University (US) | 2015-06-24 | — | — | EP | disclosed |
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-08-29 | — | — | US | disclosed |
| WO-2012058211-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | NOX4, NOX5, NQO2 | XDH 11/4885ALDH1A1 458/4885MPO 10/4885 |
| US-20150110723-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | NOX3, NOX1, NOX5 | XDH 10/4885ALDH1A1 659/4885MPO 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.