Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.69 |
| ▸ | CASP1 | P29466 | 1/20 | 0.64 |
| ▸ | CASP4 | P49662 | 1/20 | 0.64 |
| ▸ | CASP5 | P51878 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1883482 | 1.00 | SIGMAR1 (0.77) | SIGMAR1ALDH1A1KDM4EHRH3CASP1 | |
| Hydrochloric Acid SCHEMBL16825187 | 0.98 | SIGMAR1 (0.74) | SIGMAR1ALDH1A1KDM4EHRH3CASP1 | |
| SCHEMBL3162705 | 0.98 | SIGMAR1 (0.79) | SIGMAR1ALDH1A1KDM4EHRH3CASP1 | |
| SCHEMBL30774908 | 0.95 | SIGMAR1 (0.79) | SIGMAR1ALDH1A1KDM4EHRH3CASP1 | |
| SCHEMBL19206069 | 0.92 | SIGMAR1 (0.70) | SIGMAR1ALDH1A1KDM4EHRH3CASP1 | |
| SCHEMBL28186295 | 0.91 | SIGMAR1 (0.90) | SIGMAR1ALDH1A1KDM4ECASP1CASP4 | |
| SCHEMBL20804357 | 0.91 | SIGMAR1 (0.90) | SIGMAR1ALDH1A1KDM4ECASP1CASP4 | |
| Benzylamine SCHEMBL28105111 | 0.91 | SIGMAR1 (0.74) | SIGMAR1ALDH1A1KDM4EHRH3CASP1 | |
| SCHEMBL24495483 | 0.89 | DRD4 (0.68) | SIGMAR1ALDH1A1KDM4EHRH3CASP1 | |
| SCHEMBL19206085 | 0.88 | SIGMAR1 (0.64) | SIGMAR1ALDH1A1KDM4EHRH3CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787785-B2 | Pyrazolopyridine derivatives and uses thereof | NOVARTIS AG (CH) | 2023-10-17 | — | — | US | claimed |
| US-20230108325-A1 | Pyrazolopyridine Derivatives and Uses thereof | NOVARTIS AG (CH) | 2023-04-06 | — | — | US | claimed |
| US-20250282762-A1 | PYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2025-09-11 | — | — | US | disclosed |
| US-12252482-B2 | Pyrazolopyridine derivatives and uses thereof | NOVARTIS AG (CH) | 2025-03-18 | — | — | US | disclosed |
| US-20250002479-A1 | PYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2025-01-02 | — | — | US | disclosed |
| US-12172984-B2 | Pyrazolopyridine derivatives and uses thereof | NOVARTIS AG (CH) | 2024-12-24 | — | — | US | disclosed |
| US-11787785-B2 | Pyrazolopyridine derivatives and uses thereof | NOVARTIS AG (CH) | 2023-10-17 | — | — | US | disclosed |
| US-20230321067-A1 | DOSING REGIMEN COMPRISING 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2023-10-12 | — | — | US | disclosed |
| US-20230108325-A1 | Pyrazolopyridine Derivatives and Uses thereof | NOVARTIS AG (CH) | 2023-04-06 | — | — | US | disclosed |
| US-11299490-B2 | Benzenesulfonamide compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2022-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787785-B2 | Pyrazolopyridine derivatives and uses thereof | HBZ, ZFX, WIZ | SIGMAR1 2433/4885ALDH1A1 1243/4885KDM4E 2746/4885 |
| US-12172984-B2 | Pyrazolopyridine derivatives and uses thereof | HBZ, ZFX, WIZ | SIGMAR1 2433/4885ALDH1A1 1243/4885KDM4E 2746/4885 |
| US-12252482-B2 | Pyrazolopyridine derivatives and uses thereof | HBZ, ZFX, WIZ | SIGMAR1 2433/4885ALDH1A1 1243/4885KDM4E 2746/4885 |
| US-20250282762-A1 | PYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF | HBZ, ZFX, WIZ | SIGMAR1 2433/4885ALDH1A1 1243/4885KDM4E 2746/4885 |
| US-20230321067-A1 | DOSING REGIMEN COMPRISING 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES | IKZF1, IKZF2, IKZF3 | SIGMAR1 3897/4885ALDH1A1 2551/4885KDM4E 335/4885 |
| US-20230108325-A1 | Pyrazolopyridine Derivatives and Uses thereof | HBZ, ZFX, WIZ | SIGMAR1 2433/4885ALDH1A1 1243/4885KDM4E 2746/4885 |
| US-11299490-B2 | Benzenesulfonamide compounds and their use as therapeutic agents | SCN1A, SCN1B, SCN2B | SIGMAR1 3293/4885ALDH1A1 2797/4885KDM4E 1252/4885 |
| US-20250002479-A1 | PYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF | HBZ, ZFX, WIZ | SIGMAR1 2433/4885ALDH1A1 1243/4885KDM4E 2746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.