Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.55 |
| ▸ | CCR8 | P51685 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548538 | 0.80 | KDM4E (0.52) | CCR1CCR8L3MBTL1ALDH1A1CASP6 | |
| SCHEMBL31378859 | 0.78 | CCR1 (0.56) | CCR1CCR8L3MBTL1ALDH1A1CASP6 | |
| SCHEMBL17092795 | 0.77 | CCR1 (0.55) | CCR1CCR8L3MBTL1ALDH1A1CASP6 | |
| SCHEMBL3565423 | 0.77 | ALDH1A1 (0.58) | CCR1CCR8L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL31135866 | 0.77 | PSMD14 (0.62) | CCR1CCR8L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL2938512 | 0.77 | LMNA (0.56) | CCR1CCR8L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL11087820 | 0.77 | PSMD14 (0.62) | CCR1CCR8L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL15007502 | 0.77 | KDM4E (0.48) | CCR1CCR8L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL22270741 | 0.77 | CCR1 (0.55) | CCR1CCR8L3MBTL1ALDH1A1CASP6 | |
| SCHEMBL13977909 | 0.77 | PSMD14 (0.62) | CCR1CCR8L3MBTL1ALDH1A1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2149574-B1 | 2, 6-DINITROGEN-CONTAINING SUBSTITUTED PURINE DERIVATIVES, THE PREPARATION AND USES THEREOF | ZHEJIANG MED XINCHANG PHARM (CN) | 2015-12-02 | — | — | EP | disclosed |
| US-8580763-B2 | 2, 6-dinitrogen-containing substituted purine derivatives, the preparation and uses thereof | ZHANGGUI WU (CN) | 2013-11-12 | — | — | US | disclosed |
| US-20100144663-A1 | 2, 6-Dinitrogen-Containing Substituted Purine Derivatives, The Preparation And Uses Thereof | ZHE JIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2010-06-10 | — | — | US | disclosed |
| EP-2149574-A1 | 2, 6-DINITROGEN-CONTAINING SUBSTITUTED PURINE DERIVATIVES, THE PREPARATION AND USES THEREOF | ZheJiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory (CN) | 2010-02-03 | — | — | EP | disclosed |
| CN-101289449-A | 2, 6-dinitrogen-containing substituted purine derivative and preparation method and application thereof | ZHEJIANG MEDICINE CO LTD (CN) | 2008-10-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144663-A1 | 2, 6-Dinitrogen-Containing Substituted Purine Derivatives, The Preparation And Uses Thereof | PNP, NUDT1, DPYD | CCR1 3929/4885CCR8 4015/4885L3MBTL1 2139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.