Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MITF | O75030 | 3/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451786 | 0.84 | HTT (0.46) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL24779602 | 0.81 | ALDH1A1 (0.64) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL29451272 | 0.78 | KDM4E (0.49) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL29451589 | 0.78 | RAB9A (0.48) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL29451407 | 0.76 | RAB9A (0.46) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL29451457 | 0.74 | RAB9A (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL24640867 | 0.74 | NPBWR1 (0.68) | ALDH1A1SMN1; SMN2HTTNPBWR1 | |
| SCHEMBL29451604 | 0.74 | RAB9A (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL29451328 | 0.68 | MEN1 (0.51) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL2895158 | 0.68 | ALDH1A1 (0.61) | NPC1RAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |