Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 2/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10538992 | 1.00 | TSHR (0.47) | TSHRSMN1; SMN2TDP1HSD17B10CYP3A4 | |
| SCHEMBL8764002 | 0.86 | TSHR (0.47) | TSHRSMN1; SMN2TDP1HSD17B10CYP3A4 | |
| SCHEMBL11755785 | 0.84 | TSHR (0.49) | TSHRSMN1; SMN2TDP1HSD17B10CYP3A4 | |
| SCHEMBL28203910 | 0.82 | TSHR (0.47) | TSHRSMN1; SMN2TDP1HSD17B10CYP3A4 | |
| SCHEMBL4815935 | 0.79 | TDP1 (0.54) | TSHRSMN1; SMN2TDP1HSD17B10CYP3A4 | |
| SCHEMBL30908227 | 0.79 | TSHR (0.56) | TSHRSMN1; SMN2TDP1HSD17B10ALDH1A1 | |
| SCHEMBL8764130 | 0.79 | TSHR (0.56) | TSHRSMN1; SMN2TDP1HSD17B10ALDH1A1 | |
| SCHEMBL4091751 | 0.76 | TDP2 (0.39) | TSHRTDP1HSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL31058324 | 0.76 | VCAM1 (0.45) | TSHRSMN1; SMN2TDP1HSD17B10CYP3A4 | |
| SCHEMBL3192674 | 0.74 | TSHR (0.65) | TSHRSMN1; SMN2TDP1HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |