Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.39 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451475 | 1.00 | PRMT5 (0.39) | PRMT5WDR77RIOK1KMOKDM4E | |
| SCHEMBL29452082 | 0.83 | ALDH1A1 (0.44) | PRMT5WDR77RIOK1KMOKDM4E | |
| SCHEMBL29452023 | 0.83 | ALDH1A1 (0.44) | PRMT5WDR77RIOK1KMOKDM4E | |
| SCHEMBL29452015 | 0.83 | ALDH1A1 (0.44) | PRMT5WDR77RIOK1KMOKDM4E | |
| SCHEMBL31180570 | 0.77 | KMO (0.38) | PRMT5WDR77RIOK1KMOKDM4E | |
| SCHEMBL29451634 | 0.76 | ALDH1A1 (0.41) | PRMT5WDR77KDM4ENPC1ALDH1A1 | |
| SCHEMBL29452152 | 0.76 | ALDH1A1 (0.41) | PRMT5WDR77KDM4ENPC1ALDH1A1 | |
| SCHEMBL31015065 | 0.75 | KMO (0.37) | PRMT5WDR77RIOK1KMOKMT2A | |
| SCHEMBL16584237 | 0.73 | KDM4E (0.38) | KDM4ENPC1ALDH1A1NPSR1KMT2A | |
| SCHEMBL16584238 | 0.73 | KDM4E (0.38) | KDM4ENPC1ALDH1A1NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |