Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.52 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212524 | 1.00 | ALDH1A1 (0.52) | ALDH1A1TSHRGLAPDE2APDE5A | |
| SCHEMBL7212541 | 0.83 | ALDH1A1 (0.48) | ALDH1A1TSHRGLAPDE2APDE5A | |
| SCHEMBL7212793 | 0.83 | ALDH1A1 (0.59) | ALDH1A1TSHRGLAPDE2APDE5A | |
| SCHEMBL29451339 | 0.82 | TRPV4 (0.41) | ALDH1A1TSHRGLACYP3A4ALOX15 | |
| SCHEMBL7213957 | 0.81 | ALDH1A1 (0.46) | ALDH1A1TSHRGLAPDE2APDE5A | |
| SCHEMBL29451638 | 0.79 | ALDH1A1 (0.59) | ALDH1A1TSHRPDE2APDE5ACYP3A4 | |
| SCHEMBL7212546 | 0.79 | ALDH1A1 (0.55) | ALDH1A1TSHRPDE2APDE5ACYP3A4 | |
| SCHEMBL7212568 | 0.79 | ALDH1A1 (0.59) | ALDH1A1TSHRPDE2APDE5ACYP3A4 | |
| SCHEMBL7212867 | 0.79 | ALDH1A1 (0.55) | ALDH1A1TSHRPDE2APDE5ACYP3A4 | |
| SCHEMBL29451866 | 0.79 | VCAM1 (0.59) | ALDH1A1TSHRGLAPDE2APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |