Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452287 | 0.85 | MEN1 (0.46) | KMT2AMEN1POLBSMN1; SMN2PTGS2 | |
| SCHEMBL29452234 | 0.83 | KDM4E (0.37) | KMT2AMEN1POLBSMN1; SMN2KDM4E | |
| SCHEMBL29451550 | 0.81 | KMT2A (0.51) | KMT2AMEN1GAAPOLBSMN1; SMN2 | |
| SCHEMBL10815353 | 0.79 | MEN1 (0.49) | KMT2AMEN1GAAPOLBSMN1; SMN2 | |
| SCHEMBL2888331 | 0.71 | SMN1; SMN2 (0.51) | KMT2AMEN1GAAPOLBSMN1; SMN2 | |
| SCHEMBL29451328 | 0.70 | MEN1 (0.51) | KMT2AMEN1GAAPOLBSMN1; SMN2 | |
| SCHEMBL2895158 | 0.70 | ALDH1A1 (0.61) | KMT2AMEN1GAAPOLBSMN1; SMN2 | |
| SCHEMBL29452000 | 0.70 | POLB (0.51) | KMT2AMEN1GAAPOLBSMN1; SMN2 | |
| SCHEMBL2896401 | 0.70 | ALDH1A1 (0.66) | KMT2AMEN1GAAPOLBSMN1; SMN2 | |
| SCHEMBL13844729 | 0.70 | MEN1 (0.51) | KMT2AMEN1GAAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |