Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451935 | 0.83 | KMT2A (0.46) | KDM4EHSD17B10ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL29451810 | 0.82 | MITF (0.47) | KDM4EHSD17B10HPGDMITFRAB9A | |
| SCHEMBL29451678 | 0.74 | HTT (0.49) | KDM4EHSD17B10HPGDMITFRAB9A | |
| SCHEMBL29451928 | 0.74 | KDM4E (0.45) | KDM4EHSD17B10HPGDMITFRAB9A | |
| SCHEMBL29452287 | 0.66 | MEN1 (0.46) | HPGDMITFRAB9ANPC1MAPT | |
| SCHEMBL2888709 | 0.64 | NPC1 (0.75) | KDM4EHSD17B10HPGDMITFRAB9A | |
| SCHEMBL29451417 | 0.64 | KMO (0.44) | KDM4EHSD17B10HPGDKMOMAPT | |
| SCHEMBL2888078 | 0.64 | HTT (0.69) | HPGDMITFRAB9ANPC1TP53 | |
| SCHEMBL10814794 | 0.64 | HTT (0.48) | MITFRAB9ANPC1TP53MAPT | |
| SCHEMBL31648588 | 0.63 | GRIN1 (0.45) | KDM4EHSD17B10HPGDEPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |