SCHEMBL29454245

SCHEMBL29454245

Cc1c(N)cc(F)cc1Cc1ccc(Cl)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.44
MAPT P10636 1/20 0.44
KMT2A Q03164 1/20 0.44
HSP90AB1 P08238 1/20 0.39
MPO P05164 1/20 0.38
ADCY10 Q96PN6 2/20 0.38
POLB P06746 1/20 0.37
CNR2 P34972 1/20 0.36
HTR2A P28223 2/20 0.36
SLC6A4 P31645 2/20 0.36
KCNH2 Q12809 1/20 0.36
CYP3A4 P08684 2/20 0.36
ALDH1A1 P00352 1/20 0.36
MDM4 O15151 1/20 0.35
TP53 P04637 1/20 0.35
MDM2 Q00987 1/20 0.35
TAAR1 Q96RJ0 1/20 0.34
SLC6A2 P23975 1/20 0.34
HRH1 P35367 1/20 0.34
HTR2B P41595 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22232191 1.00 MEN1 (0.44) MEN1MAPTKMT2AHSP90AB1MPO
SCHEMBL22232129 0.88 MPO (0.41) MAPTMPOADCY10CNR2CYP3A4
SCHEMBL22232363 0.86 RET (0.40) MAPTPOLBCNR2SLC6A4CYP3A4
SCHEMBL22231891 0.84 MPO (0.44) MEN1MAPTKMT2AHSP90AB1MPO
SCHEMBL22231962 0.83 DPP4 (0.36) MAPTHTR2ACYP3A4ALDH1A1TAAR1
SCHEMBL22231733 0.83 ADCY10 (0.42) MEN1MAPTKMT2AMPOADCY10
SCHEMBL22232549 0.83 KMT2A (0.42) MEN1MAPTKMT2AHSP90AB1MPO
SCHEMBL22232508 0.83 PNMT (0.43) MAPTMPOADCY10CYP3A4TAAR1
SCHEMBL22232006 0.83 CYP3A4 (0.40) MAPTMPOADCY10HTR2ASLC6A4
SCHEMBL29454343 0.83 CYP3A4 (0.40) MAPTMPOADCY10HTR2ASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof PI INDUSTRIES LTD. (IN) 2026-02-10 US disclosed
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2022-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF H1-3, PRMT7, PFAS MEN1 1657/4885MAPT 3811/4885KMT2A 438/4885
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof CBR1, CBR3, HCCS MEN1 3874/4885MAPT 4483/4885KMT2A 3264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.