SCHEMBL29454253

SCHEMBL29454253

Cc1c(N)cc(F)cc1Cc1cccc(F)c1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.45
MPO P05164 1/20 0.45
MAOB P27338 2/20 0.44
IDO1 P14902 2/20 0.43
AGXT P21549 2/20 0.43
ADCY10 Q96PN6 1/20 0.42
IDH1 O75874 1/20 0.41
PDE3B Q13370 1/20 0.40
PDE3A Q14432 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
DAO P14920 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
HTR6 P50406 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22232600 1.00 TAAR1 (0.45) TAAR1MPOMAOBIDO1AGXT
SCHEMBL22231831 0.89 IDH1 (0.47) TAAR1MPOMAOBIDO1AGXT
SCHEMBL22231998 0.89 MPO (0.44) TAAR1MPOIDO1DAOHTR6
SCHEMBL22231768 0.86 TAAR1 (0.41) TAAR1MAOBIDO1AGXT
SCHEMBL22232508 0.86 PNMT (0.43) TAAR1MPOIDO1AGXTADCY10
SCHEMBL29454346 0.86 PNMT (0.43) TAAR1MPOIDO1AGXTADCY10
SCHEMBL22231741 0.83 HTR2A (0.48) TAAR1MPOMAOBIDO1DAO
SCHEMBL22232044 0.83 MAOB (0.48) TAAR1MPOMAOBIDO1AGXT
SCHEMBL22232214 0.82 MPO (0.45) MPOMAOBIDH1
SCHEMBL22232129 0.81 MPO (0.41) TAAR1MPOMAOBADCY10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof PI INDUSTRIES LTD. (IN) 2026-02-10 US disclosed
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2022-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF H1-3, PRMT7, PFAS TAAR1 1374/4885MPO 1451/4885MAOB 74/4885
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof CBR1, CBR3, HCCS TAAR1 445/4885MPO 2443/4885MAOB 1930/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.