SCHEMBL29454346

SCHEMBL29454346

Cc1c(N)cc(F)cc1Cc1cccc(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PNMT P11086 2/20 0.43
MPO P05164 1/20 0.42
TAAR1 Q96RJ0 2/20 0.41
ADCY10 Q96PN6 1/20 0.41
GRIN2B Q13224 2/20 0.40
CYP3A4 P08684 2/20 0.40
IDO1 P14902 2/20 0.40
AGXT P21549 2/20 0.40
MAPT P10636 1/20 0.40
MAPK1 P28482 1/20 0.40
AOC3 Q16853 1/20 0.40
NOS2 P35228 1/20 0.39
PNP P00491 1/20 0.39
BACE1 P56817 1/20 0.38
PDE3B Q13370 1/20 0.38
PDE3A Q14432 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22232508 1.00 PNMT (0.43) PNMTMPOTAAR1ADCY10GRIN2B
SCHEMBL22232600 0.86 TAAR1 (0.45) MPOTAAR1ADCY10IDO1AGXT
SCHEMBL29454253 0.86 TAAR1 (0.45) MPOTAAR1ADCY10IDO1AGXT
SCHEMBL22231998 0.84 MPO (0.44) MPOTAAR1IDO1
SCHEMBL22232614 0.84 PNMT (0.46) PNMTMPOTAAR1ADCY10CYP3A4
SCHEMBL22232191 0.83 MEN1 (0.44) MPOTAAR1ADCY10CYP3A4MAPT
SCHEMBL29454245 0.83 MEN1 (0.44) MPOTAAR1ADCY10CYP3A4MAPT
SCHEMBL22231768 0.82 TAAR1 (0.41) TAAR1IDO1AGXTMAPK1
SCHEMBL22232481 0.79 MAPT (0.42) PNMTMPOTAAR1ADCY10CYP3A4
SCHEMBL29454347 0.79 MAPT (0.42) PNMTMPOTAAR1ADCY10CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof PI INDUSTRIES LTD. (IN) 2026-02-10 US disclosed
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2022-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF H1-3, PRMT7, PFAS PNMT 103/4885MPO 1451/4885TAAR1 1374/4885
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof CBR1, CBR3, HCCS PNMT 731/4885MPO 2443/4885TAAR1 445/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.